- Tripeptide-1
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- $0.00 / 1kg
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2025-02-16
- CAS:72957-37-0
- Min. Order: 0.10000000149011612kg
- Purity: ≥99%
- Supply Ability: 20tons
- Tripeptide-1
-
- $1.00 / 1kg
-
2025-02-14
- CAS:72957-37-0
- Min. Order: 0.0001kg
- Purity: 99%
- Supply Ability: 50kg
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| | Tripeptide-1 Basic information |
| Product Name: | Tripeptide-1 | | Synonyms: | H-GLY-HIS-LYS-OH ACETATE SALT;H-GLY-HIS-LYS-OH ACOH;GLY-HIS-LYS ACETATE;GLY-HIS-LYS ACETATE SALT;GLY-HIS-LYS ACOH H2O;GLYCYL-L-HISTIDYL-L-LYSINE ACETATE;LIVER CELL GROWTH FACTOR;LIVER CELL GROWTH FACTOR ACETATE SALT | | CAS: | 72957-37-0 | | MF: | C16H28N6O6 | | MW: | 400.44 | | EINECS: | 277-125-4 | | Product Categories: | Amino Acid Derivatives;72957-37-0 | | Mol File: | 72957-37-0.mol |  |
| | Tripeptide-1 Chemical Properties |
| storage temp. | -20°C | | form | powder | | color | white | | biological source | synthetic (organic) | | Water Solubility | H2O: soluble 0.5mg/mL, clear, colorless | | Sequence | Gly-His-Lys | | InChIKey | MGNUTAFMLGJBGV-ACMTZBLWSA-N | | SMILES | C(=O)(O)C.[C@@H](NC(=O)CN)(C(=O)N[C@H](C(=O)O)CCCCN)CC1N=CNC=1 |&1:4,13,r| | | CAS DataBase Reference | 72957-37-0(CAS DataBase Reference) |
| | Tripeptide-1 Usage And Synthesis |
| Description | Tripeptide-1 is a small peptide composed of three amino acids (glycine-histidine-lysine or GHK) and is known for type I collagen fragments. When collagen fragment peptides (GHK) are added, it may mistakenly lead the skin to think that collagen has been broken down, resulting in more collagen. Therefore, tripeptide-1 is believed to stimulate collagen production in the skin. More collagen will reduce wrinkles on the face, which will improve the condition of the skin. | | Chemical Properties | White powder | | Uses | Liver Cell Growth Factor | | Uses | Gly-His-Lys acetate salt has been used:
- individually or as a complex with copper to test its effect on cytokines production in the human normal fibroblasts cell lines
- as a model peptide in N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine based capillary electrophoresis separation studies
- as a component of Coon′s modified Ham′s F-12 medium for culturing Fischer rat thyroid follicular cell line, FRTL-5
| | General Description | Gly-His-Lys is a tripeptide present at ～200ng/ml in association with α-globulin and albumin, in human blood plasma. | | Biochem/physiol Actions | Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells. GHK is also involved in quenching toxic by-products generated by lipid peroxidation. | | in vitro | In an enzyme assay, the liver growth factor, Tripeptide-1, was hydrolyzed by an aminotripeptidase purified from rat brain cytosol[1]. | | in vivo | Tripeptide-1 (1% in saline; dose = 10 mg/kg) was injected into the tail vein of male rats (number not specified). Blood samples were collected prior to dosing and for up to 60 minutes post-dosing. Plasma concentration-time profiles of Tripeptide-1 and its l-histidyl-l-lysine metabolite indicated that neither was detected in predose plasma samples. However, after intravenous (IV) injection, Tripeptide-1 was rapidly degraded to l histidyl-l-lysine, rapidly eliminated from circulating blood. It has been reported that Tripeptide-1 is unstable in human plasma and is rapidly degraded by aminopeptidases[1].
| | References | [1] Wilbur Johnson. “Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics.” International Journal of Toxicology 37 1 (2018): 102S–90S.
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| | Tripeptide-1 Preparation Products And Raw materials |
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