双(1,3-二巴比妥酸)-三次甲基氧烯洛尔
| 中文名称 | 双(1,3-二巴比妥酸)-三次甲基氧烯洛尔 |
|---|---|
| 中文同义词 | 双(1,3-二巴比妥酸)-三次甲基氧烯洛尔;双(1,3-二丁基巴比妥酸)三次甲基氧杂菁;双(1,3-贰丁基巴比妥酸)三次甲基氧杂菁;DIBAC4(3)细胞膜电位荧光探针;化合物S0859;DIBAC4(3)膜电位荧光探针 |
| 英文名称 | DIBAC4(3) |
| 英文同义词 | BIS(1,3-DIBARBITURIC ACID)-TRIMETHINE OXANOL;BIS-(1,3-DIBUTYLBARBITURIC ACID)TRIMETHINE OXONOL;DIBAC4(3);Neurodye DiBAC4(3);Bis(1,3-dibutylbarbituricacid)trimethineoxonol,sodiumsalt;1,3-Dibutyl-5-(3-(1,3-dibutyl-1,2,3,4-tetrahydro-6-hydroxy-2,4-dioxo-5-pyrimidinyl)-2-propenylidene)-2,4,6(1H,3H,5H)pyrimidinetrione;2,4,6(1h,3h,5h)-pyrimidinetrione, 1,3- dibutyl-5-[3-(1,3-dibutylhexahydro-2,4,6-trioxo-5-pyrimidinyl)- 2-propenylidene]-;2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dibutyl-5-[3-(1,3-dibutylhexahydro-2,4,6-trioxo-5-pyrimidinyl)-2-propen-1-ylidene]- |
| CAS号 | 70363-83-6 |
| 分子式 | C27H40N4O6 |
| 分子量 | 516.63 |
| EINECS号 | 1312995-182-4 |
| 相关类别 | 染料;血液学和组织学;有机试剂;中间体-有机中间体;生化试剂;Oxonol;其他 |
| Mol文件 | 70363-83-6.mol |
| 结构式 |  |
双(1,3-二巴比妥酸)-三次甲基氧烯洛尔 性质
| 熔点 | >200℃ |
|---|---|
| 沸点 | 614.3±65.0 °C(Predicted) |
| 密度 | 1.201±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 在DMF中可溶 |
| 酸度系数(pKa) | 4.80±0.20(Predicted) |
| 形态 | 粉末 |
| 颜色 | 橙色 |
| 最大波长(λmax) | 493 nm |
| 生物领域应用 | Measuring membrane potential; HCN channel modulators; BK channel activator; treating Alzheimer’s disease; antimicrobial susceptibility test; ion channel screening assays; hERG channel assay |
DiBAC4(3) 是一种电压敏感的荧光染料 (λex=490 nm，λem=505 nm)。
The membrane hyperpolarization induced by 10 μM Evans blue (EB) in HEKBKα is clearly observed with DiBAC4(3), while the change in membrane potential (MP) by addition of 3 mM tetraethylammonium chloride (TEA) appears more slowly than that measured with microelectrode. The time to peak of hyperpolarization is 2.3±0.9 s (n=4) and 35.0±2.6 s (n=12, P<0.01) by the measurements with microelectrodes and DiBAC4(3), respectively.
安全信息
| WGK Germany | 3 |
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