Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:Metiazinic acid;Metiazinic acid CAS:13993-65-2 Purity:98% Package:5 mg
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Company Name: |
Specs
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Tel: |
+31 15 251 8111 |
Email: |
info@specs.net |
Products Intro: |
Product Name:(10-methyl-10H-phenothiazin-2-yl)acetic acid CAS:13993-65-2 Package:20mg
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| metiazinic acid Basic information |
Product Name: | metiazinic acid | Synonyms: | metiazinic acid;Metiazinic;(10-METHYL2-PHENOTHIAZINYL)ACETICACID;Ambrunate;Metian;Novartril;RP 16091;Soridermal | CAS: | 13993-65-2 | MF: | C15H13NO2S | MW: | 271.33 | EINECS: | 2377950 | Product Categories: | | Mol File: | 13993-65-2.mol | ![metiazinic acid Structure](CAS/GIF/13993-65-2.gif) |
| metiazinic acid Chemical Properties |
Melting point | 146℃ | Boiling point | 482.6±44.0 °C(Predicted) | density | 1.2237 (rough estimate) | refractive index | 1.7500 (estimate) | pka | 4.12±0.10(Predicted) | Water Solubility | 31mg/L(30 ºC) |
Toxicity | LD50 in mice, rats (mg/kg): 800, ~500 orally (Joulou) |
| metiazinic acid Usage And Synthesis |
Originator | Soripan,Specia,France,1970 | Definition | ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group. | Manufacturing Process | 10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and
A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's
reaction (action of sulfur and morpholine, followed by hydrolysis) employing
10-methyl-3-acetylphenthiazine as starting material. | Therapeutic Function | Antiinflammatory | Trade name | Roimal (Kantoishi, Japan),
Soripal (Torii, Japan). | Synthesis | Metiazinic acid is prepared via
the Willgerodt reaction (sulfur and morpholine)
from 2-acetyl-10-methylphenothiazine.
![Synthesis of metiazinic acid Synthesis of metiazinic acid](/NewsImg/2024-03-16/6384618406410862654854862.png) | Dosage | Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of
0.75 – 1.5 g/d. |
| metiazinic acid Preparation Products And Raw materials |
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