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| | 6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Basic information |
| Product Name: | 6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE | | Synonyms: | 6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE;N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide;N-Acetyl-4-hydroxy-2-methyl-6-quinolinamine;N-(4-hydroxy-2-Methylquinolin-6-yl)acetaMide;N-(2-methyl-4-oxo-1H-quinolin-6-yl)acetamide;6-Acetamido-2-methyl-4-hydroxyquinoline;Acetamide, N-(4-hydroxy-2-methyl-6-quinolinyl)-;n-(2-Methyl-4-oxo-1,4-dihydroquinolin-6-yl)acetamide | | CAS: | 1140-81-4 | | MF: | C12H12N2O2 | | MW: | 216.24 | | EINECS: | | | Product Categories: | | | Mol File: | 1140-81-4.mol |  |
| | 6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Chemical Properties |
| Melting point | >300 °C | | Boiling point | 496.0±40.0 °C(Predicted) | | density | 1.314±0.06 g/cm3(Predicted) | | solubility | Ethyl Acetate; Toluene | | pka | 4.29±0.40(Predicted) | | form | Solid | | color | Yellow |
| | 6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Usage And Synthesis |
| Uses | N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells. | | Synthesis Reference(s) | Journal of the American Chemical Society, 70, p. 4065, 1948 DOI: 10.1021/ja01192a031 |
| | 6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Preparation Products And Raw materials |
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