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| | AMANTANIUM BROMIDE Basic information |
| Product Name: | AMANTANIUM BROMIDE | | Synonyms: | AMANTANIUM BROMIDE;Amantanil bromidum;inhibit,Amantanium bromide,Amantanium,Inhibitor | | CAS: | 58158-77-3 | | MF: | C25H46BrNO2 | | MW: | 472.54224 | | EINECS: | | | Product Categories: | | | Mol File: | 58158-77-3.mol |  |
| | AMANTANIUM BROMIDE Chemical Properties |
| Melting point | 182-184° | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| Toxicity | LD50 orally in mice: 910 mg/kg (Rovati) |
| | AMANTANIUM BROMIDE Usage And Synthesis |
| Description | Amantanium bromide is a quaternary ammonium antibacterial/antifugal agent useful
as a surgical antiseptic and for the topical therapy of mucous and cutaneous
infections. It appears somewhat more effective than cetylpyridinium chloride and
benzalkonium chloride. | | Originator | Rotta Research (Italy) | | Manufacturing Process | A solution of 21.7 g (0.11 mole) 1-adamantanecarboxylic acid chloride in 100
ml ether was added to a solution of 19.4 g (0.22 mole) 2-
dimethylaminoethanol in 200 ml ether. The reaction mixture was stirred
overnight at room temperature. Then additional 15.0 g (0.17 mole) 2-
dimethylaminoethanol was added and the reaction mixture again stirred
overnight. The reaction mixture was poured into 300 ml water and treated
with 20 ml of 10% NaOH solution. From the ether layer was recovered 23.0 g
of 2-dimethylaminoethyl 1-adamantanecarboxylate as oil.
The 2-dimethylaminoethyl 1-adamantanecarboxylate was mixed with 1-
bromodecan and allowed to stand for about 6 weeks. The resultant crystalline
mass was washed with ether and dried to gave 2-(1’-
adamantanecarbonyloxy)ethyldimethyldecylammonium bromide as white
crystals, melting point 183°-184.5°C (two recrystallizations from ethyl
acetate). | | Brand name | AMANTOL | | Therapeutic Function | Antiseptic |
| | AMANTANIUM BROMIDE Preparation Products And Raw materials |
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