| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Bufetolol
CAS:53684-49-4
Purity:NULL Package:10mg;1mg;2.5mg;25mg;50mg;5mg Remarks:NULL
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Bufetolol
CAS:53684-49-4
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
|
| Company Name: |
United States Biological
|
| Tel: |
800.520.3011 or 781.639.5092 |
| Email: |
chemicals@usbio.net |
| Products Intro: |
Product Name:Bufetolol
CAS:53684-49-4
|
Bufetolol manufacturers
- Bufetolol
-
- $1980.00 / 50mg
-
2024-10-28
- CAS:53684-49-4
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Bufetolol Basic information |
| Product Name: | Bufetolol | | Synonyms: | Bufetolol;2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-;1-[2-(Oxolan-2-ylmethyloxy)phenyloxy]-3-(tert-butylamino)-2-propanol;2-[3-(tert-Butylamino)-2-hydroxypropyloxy]-1-[(tetrahydrofuran-2-ylmethyl)oxy]benzene;N-tert-Butyl-2-hydroxy-3-[o-(tetrahydrofuran-2-ylmethyloxy)phenoxy]-1-propanamine | | CAS: | 53684-49-4 | | MF: | C18H29NO4 | | MW: | 323.43 | | EINECS: | | | Product Categories: | | | Mol File: | 53684-49-4.mol |  |
| | Bufetolol Chemical Properties |
| Boiling point | bp0.07 180-186° | | density | 1.081±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Methanol (Slightly), | | form | Oil | | pka | 13.91±0.20(Predicted) | | color | Colourless |
| | Bufetolol Usage And Synthesis |
| Originator | Adobiol,Yoshitomi,Japan,1974 | | Uses | Bufetolol is a β-adrenergic blocking agent and it inhibits the activation of adenyl cyclase. | | Definition | ChEBI: Bufetolol is an aromatic ether. | | Manufacturing Process | The preparation of a similar compound in which a methoxyethoxy group
replaces the tetrahydrofurfuryloxy group in Bufetrol is described in the
following example. Nine grams of o-(2-methoxyethoxy)phenol is suspended in
50 milliliters of water containing 3.7 grams of potassium hydroxide, and 5.5
grams of epichlorhydrin is added thereto with stirring. The mixture is stirred
at room temperature for 7 hours, and then extracted with two 50 milliliter
portions of benzene. The extract is washed with water, dried over anhydrous
magnesium sulfate and the benzene is distilled off to give 8.5 grams of oily 1-
(2,3-epoxypropoxy)-2-(2-methoxyethoxy)benzene showing nD
20 = 1.5257.
This compound has the methoxyethoxy group in place of the 2-
tetrahydrofurfuryloxy group in Bufetrol.
To a solution of 1-(2,3-epoxypropoxy)-2-(2-tetrahydrofurfuryloxy)benzene in
methanol are added tert-butylamine and water, the mixture is allowed to
stand at 25°-30°C for 72 hours, and then the methanol is distilled off. The
residue is dissolved in toluene and the solution is extracted twice with 5%
oxalic acid. The aqueous extract is dried over potassium carbonate and
concentrated to give Bufetrol. | | Therapeutic Function | Antiarrhythmic |
| | Bufetolol Preparation Products And Raw materials |
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