Pifoxime

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.com
Products Intro: Product Name:Pifoxime
CAS:31224-92-7
Purity:详情请点击官网 Package:1 mg
Company Name: Lanospharma Laboratories Co.,Ltd  
Tel: 13440048448
Email: sales@lanospharma.com
Products Intro:
Pifoxime Basic information
Product Name:Pifoxime
Synonyms:Pifoxime;1-[[4-[1-(Hydroxyimino)ethyl]phenoxy]acetyl]piperidine;Flamanil;LF-77;Pixifenide;SW-77;Ethanone, 2-[4-[1-(hydroxyimino)ethyl]phenoxy]-1-(1-piperidinyl)-
CAS:31224-92-7
MF:C15H20N2O3
MW:276.33
EINECS:
Product Categories:
Mol File:31224-92-7.mol
Pifoxime Structure
Pifoxime Chemical Properties
Boiling point 494.7±30.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
pka11.50±0.70(Predicted)
Safety Information
MSDS Information
Pifoxime Usage And Synthesis
OriginatorFlamanil ,Salvoxyl-Wander, France ,1975
Manufacturing Process(A) Preparation of p-Acetylphenoxyacetic Acid: p-Hydroxy-acetophenone is treated with chloroacetic acid in aqueous solution in the presence of sodium hydroxide. The desired acid is then isolated from its sodium salt in a total yield of 80 to 82%, excess of p-hydroxy-acetophenone having been extracted with methylene chloride.
(B) Preparation of Methyl p-Acetylphenoxy-Acetate: A mixture of 80 g of the acid obtained in (A) and 200 ml of methyl alcohol in 600 ml of dichloromethane is refluxed in the presence of sulfuric acid. The desired ester is isolated in accordance with a method known per se, and recrystallized. When the refluxing period is 12 hours, the ester is obtained with a yield of 70%. When the refluxing period is 18 hours, the yield for this ester is 85%.
(C) Preparation of N-(p-Acetylphenoxy-Acetyl)-Piperidine: The ester from (B) is refluxed for 8 hours with 2.5 mols of thoroughly dried piperidine. Then 1 volume of water is added and the product is left to crystallize in the cold. The desired amide is obtained in an 80% yield.
(D) Preparation of N-(p-[1-Isonitrosoethyl]-Phenoxy-Acetyl)-Piperidine: The amide from (C) is refluxed for 5 hours with technical (98%) hydroxylamine and alcohol denatured with methanol. The desired product is obtained in a 75% yield.
In semiindustrial synthesis, to achieve better yields, it is possible to omit (A), by directly preparing the ester (B) by reaction of p-hydroxy acetophenone on ethyl 2-bromoacetate in the presence of potassium carbonate in butanone. The yield of ester is 90%, and elimination of excess of phydroxyacetophenone is effected by washing with sodium hydroxide.
Therapeutic FunctionAntiinflammatory
Pifoxime Preparation Products And Raw materials
Raw materialsMethanol-->4'-Hydroxyacetophenone-->Piperidine-->HYDROXYLAMINE-->Chloroacetic acid
Tag:Pifoxime(31224-92-7) Related Product Information
4-ETHOXYBENZALDEHYDE OXIME 2-OXO-2-PIPERIDIN-1-YLETHANOL Pifoxime