人参皂苷RO
中文名称 | 人参皂苷RO |
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中文同义词 | 人参皂苷RO;竹节参皂苷V;竹节参苷V;人参皂苷RO(标准品);人参皂苷RO、 竹节参苷V;人参皂苷RO(分析标准品);人参皂苷RO/竹节参苷V 标准品;人参皂苷RO对照品, |
英文名称 | GinsenosideRo |
英文同义词 | (3beta)-28-(beta-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosiduronic acid;Chikusetsusaponin 5;ChikusetsusaponinV;PolysciasaponinP3;β-D-Glucopyranosiduronic acid, (3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl2-O-β-D-glucopyranosyl-;28-(β-D-Glucopyranosyloxy)-28-oxo-5α-olean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid;28-(β-D-Glucopyranosyloxy)-28-oxoolean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid;3β-(2-O-β-D-Glucopyranosyl-β-D-glucopyranuronosyloxy)oleana-12-ene-28-oic acid 28-β-D-glucopyranosyl ester |
CAS号 | 34367-04-9 |
分子式 | C48H76O19 |
分子量 | 957.11 |
EINECS号 | |
植物来源 | 人参 |
相关类别 | 对照品;人参皂苷系列;中药对照品;标准品;对照品,标准品;植物提取物;The group of Ginsenosides;chemical reagent;pharmaceutical intermediate;phytochemical;植提标准品;分析试剂标准品;标准品-中药标准品;标准品 -中药标准品;三萜;分析试剂-对照品;标准品,对照品;20版药典新增;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol文件 | 34367-04-9.mol |
结构式 | ![]() |
人参皂苷RO 性质
沸点 | 1018.6±65.0 °C(Predicted) |
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密度 | 1.14 |
储存条件 | Store at 2-8°C, protect from light |
溶解度 | DMSO:100 mg/mL(104.48 mM;需要超声波) |
形态 | 粉末 |
酸度系数(pKa) | 2.76±0.70(Predicted) |
颜色 | 白色 |
TXA 2
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Ca 2+
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Ginsenoside Ro in Panax ginseng is a beneficial novel Ca 2+ -antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease. Ginsenoside Ro dose-dependently reduces thrombin-stimulated platelet aggregation, and IC 50 is approximately 155 μM. Ginsenoside Ro inhibits TXA 2 production to abolish thrombin-induced platelet aggregation. Thromboxane A 2 (TXA 2 ) induces platelet aggregation and promotes thrombus formation. Ginsenoside Ro dose-dependently (50-300 μM) reduces the TXB 2 level that is induced by thrombin; Ginsenoside Ro (300 μM) inhibits the thrombin-mediated elevation in TXB 2 level by 94.9%. COX-1 activity in the absence of Ginsenoside Ro (negative control) is 2.3±0.1 nmol/mg protein. However, Ginsenoside Ro dose-dependently (50-300 μM) reduces its activity; at 300 μM, COX-1 activity is reduced by 26.4% of that of the negative control. TXA 2 synthase (TXAS) activity in the absence of Ginsenoside Ro (negative control) is 220.8±1.8 ng/mg protein/min. However, Ginsenoside Ro dose-dependently (50-300 μM) reduces its activity; at 300 μM, TXAS activity is reduced by 22.9% of that of the negative control. The inhibitory effect of Ginsenoside Ro (300 μM) on TXB 2 production (94.9%) is significantly higher than those on COX-1 (26.4%) and TXAS (22.9%) activities. To assess the toxicity of Ginsenoside Ro in Raw 264.7 cells, they are first treated with various concentrations (10 μM, 50 μM, 100 μM, and 200 μM) of Ginsenoside Ro for 24 h. Ginsenoside Ro exhibits no significant dose dependent toxicity. The effect of Ginsenoside Ro is next determined on cell viability and ROS levels, a marker of oxidative stress, following treatment with 1 μg/mL LPS. LPS reduces cell viability by ∼70% compared with nontreated controls. Pretreatment with 100 μM and 200 μM Ginsenoside Ro for 1 h prior to 1 μg/mL LPS incubation for 24 h leads to a significant increase in cell viability. The changes in ROS levels and NO production are consistent with the effects of Ginsenoside Ro on viability.
Ginsenoside Ro dissolved in water is administrated by gavage to mice at doses of 25 and 250 mg/kg/day for 4 days before i.v. injection of HT29 in order to keep blood concentrations of Ginsenoside Ro above a certain level before HT29 i.v. injection followed by 40 days of oral administration of Ginsenoside Ro to the mice. After 38 days of treatment, the animals are euthanized, and the number of pulmonary metastatic nodules is counted in addition to evaluation of toxicity of Ginsenoside Ro and mouse pathology by HT29. Ginsenoside Ro (250 mg/kg/day) produces a significant decrease in the number of tumor nodules on the lung surface, yielding inhibition rates of 88% (P [4] .
药理药效:人参主要具有大补元气,滋补强壮,安神益智,生津,复脉固脱等功效。
安全信息
海关编码 | 29389090 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S9103 | 人参皂苷RO Ginsenoside Ro | 34367-04-9 | 1mg | 1204.38元 |