柯诺辛
中文名称 | 柯诺辛 |
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中文同义词 | 柯诺辛;柯诺辛碱;柯诺辛, 钩藤碱;柯诺辛(标准品);柯诺辛,柯诺辛碱;柯诺辛碱?, 99.5%;柯诺辛对照品 |
英文名称 | Corynoxine |
英文同义词 | (16E)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester;Corynoxine;Corynoxine A;Corynoxan-16-carboxylicacid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E)-;Corynoxine, 99.5%;Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'S,7'S,8'aS)-;(E)-methyl 2-((1'S,6'S,7'S,8a'S)-6'-ethyl-2-oxo-3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate |
CAS号 | 6877-32-3 |
分子式 | C22H28N2O4 |
分子量 | 384.47 |
EINECS号 | 211-708-6 |
相关类别 | 植物提取物;对照品、标准品,植物单体,植物提取物;标准品;对照品;中药对照品;分析试剂标准品;对照品-中药对照品;生物碱;标准品 -中药标准品;分析试剂-对照品;标准品,对照品 |
Mol文件 | 6877-32-3.mol |
结构式 |
柯诺辛 性质
熔点 | 166-168℃ |
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沸点 | 560.8±50.0 °C(Predicted) |
密度 | 1.23 |
储存条件 | Store at -20°C |
溶解度 | DMSO:≥ 100 mg/mL (260.10 mM);水:< 0.1 mg/mL(不溶) |
酸度系数(pKa) | 13.61±0.60(Predicted) |
形态 | 水晶。 |
颜色 | 白色至米白色 |
Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner.
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction.
Western Blot Analysis
Cell Line: | N2a and SH-SY5Y cells |
Concentration: | 6.25, 12.5, 25 μM |
Incubation Time: | 6, 12 hours |
Result: | Induced autophagy in neuronal cell lines. |
Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice.
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.