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| | (9S)-9-Amino-9-deoxoerythromycin Basic information |
| | (9S)-9-Amino-9-deoxoerythromycin Chemical Properties |
| Melting point | 123-127°C | | Boiling point | 810.3±65.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml | | form | A solid | | pka | 13.41±0.70(Predicted) | | color | White to off-white |
| Hazard Codes | Xi,N | | Risk Statements | 41-50/53 | | Safety Statements | 26-39-60-61 | | Toxicity | mouse,LD50,intraperitoneal,120mg/kg (120mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 83, 1978. |
| | (9S)-9-Amino-9-deoxoerythromycin Usage And Synthesis |
| Chemical Properties | (9S)-9-Amino-9-deoxoerythromycin is White Solid | | Uses | (9S)-9-Amino-9-deoxoerythromycin is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. (9S)-9-Amino-9-deoxoerythromycin is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine. | | Uses | Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine. | | Uses | (9S)-9-Amino-9-deoxoerythromycin is a metabolite of Dirithromycin; an antibiotic | | Definition | ChEBI: A macrolide antibiotic that is erythromycin A in which the ketone group has been converted to the corresponding imine and then reduced to give the corresponding amino compound (the 9S diastereoisomer). |
| | (9S)-9-Amino-9-deoxoerythromycin Preparation Products And Raw materials |
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