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Mepacrine hydrochloride

Mepacrine hydrochloride Suppliers list
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Products Intro: Product Name: Mepacrine hydrochloride
CAS:6151-30-0
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Products Intro: Product Name:Mepacrine hydrochloride
CAS:6151-30-0
Purity:0.98 Package:1KG;10KG;50KG
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Products Intro: Product Name:mepacrine hydrochloride
CAS:6151-30-0
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Products Intro: Product Name:Quinacrine hydrochloride hydrate;Mepacrine Dihydrochloride Dihydrate;Quinacrine Dihydrochloride Dihydrate
CAS:6151-30-0
Package:25 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:Mepacrine hydrochloride
CAS:6151-30-0
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

Mepacrine hydrochloride manufacturers

Mepacrine hydrochloride Basic information
Product Name:Mepacrine hydrochloride
Synonyms:QUINACRINE DIHYDROCHLORIDE DIHYDRATE;QUINACRINE HYDROCHLORIDE, DIHYDRATE;6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-acridindihydr;6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridinedihydroc;atabrinehydrochloridedihydrate;hloride2h2-o;mepacrinehcl;mepacrinehydrochloridedihydrate
CAS:6151-30-0
MF:C23H36Cl3N3O3
MW:508.91
EINECS:
Product Categories:
Mol File:6151-30-0.mol
Mepacrine hydrochloride Structure
Mepacrine hydrochloride Chemical Properties
Melting point 247 °C
storage temp. Store at -20°C
solubility DMSO: 10 mg/mL (19.65 mM);;
form Solid
color Light yellow to yellow
Water Solubility 2.8 g/100 mL
CAS DataBase Reference6151-30-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-37/39
MSDS Information
ProviderLanguage
ACROS English
Mepacrine hydrochloride Usage And Synthesis
Chemical Propertiesbright yellow powder
UsesQuinacrine Dihydrochloride Dihydrate is a phophoslipase A2 inhibitor.
General DescriptionQunacrine is no longer available in theUnited States. It can be considered one of the most toxic ofthe antimalarial drugs even though, at one time, it was commonlyused. It acts at many sites within the cell includingintercalation of DNA strands, succinic dehydrogenase andmitochondrial electron transport, and cholinesterase. It maybe tumorgenic and mutagenic and has been used as a sclerosingagent. Because it is an acridine dye, quinacrine cancause yellow discoloration of the skin and urine.
in vivo

Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose[2].

Animal Model:Female SCID mice with acute myeloid leukemia (AML)-PS model[2]
Dosage:100 mg/kg
Administration:Administered by oral gavage (po); three times a week for two consecutive weeks
Result:In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
IC 50Plasmodium
Mepacrine hydrochloride Preparation Products And Raw materials
Tag:Mepacrine hydrochloride(6151-30-0) Related Product Information
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