异去氢钩藤碱
| 中文名称 | 异去氢钩藤碱 |
|---|---|
| 中文同义词 | 异去氢钩藤碱(异柯诺辛因碱 );异柯诺辛因碱;异去氢钩藤碱;异去氢钩藤碱(标准品);ISOCORYNOXEINE 异去氢钩藤碱;异去氢钩藤碱?, BR;异去氢钩藤碱(对照品);异柯诺辛因碱标准品 |
| 英文名称 | Isocorynoxeine |
| 英文同义词 | Isocorynoxeine;(16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester;(alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester;Isocorynoxeine, BR;Isocorynoxeine (7-Isocorynoxeine);Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-;Isocorynoxeine USP/EP/BP;methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate |
| CAS号 | 51014-29-0 |
| 分子式 | C22H26N2O4 |
| 分子量 | 382.46 |
| EINECS号 | |
| 相关类别 | 植提标准品;中药对照品;标准品;对照品,标准品;植物提取物;中草药成分;对照品;标准品-中药标准品;生物碱;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品 -中药标准品;标准品，对照品 |
| Mol文件 | 51014-29-0.mol |
| 结构式 |  |
异去氢钩藤碱 性质
| 沸点 | 562.7±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.25 |
| 溶解度 | DMSO：50 mg/mL（130.74 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.54±0.60(Predicted) |
| 颜色 | 白色至米白色 |
|
5-HT 2A Receptor 72.4 μM (IC 50 ) |
Isocorynoxeine inhibits 5-HT 2A receptor-mediated 5-HT currents. Isocorynoxeine prefer to interact with 5-HT 2A receptors rather than with 5-HT 2C receptors in the brain.Isocorynoxeine exhibits less potent inhibitory activity (with IC 50 values of > 100 μM) against the 5-HT 2C receptor-mediated response than the 5-HT 2A receptor-mediated response in oocytes. Isocorynoxeine dose-dependently and competitively inhibits 5-HT-evoked currents in Xenopus oocytes expressing 5-HT 2A receptors, but has less of a suppressive effect on those in oocytes expressing 5-HT 2C receptors.
The effects of Rhynchophylline, Corynoxeine, and Isocorynoxeine, isorhynchophylline-related alkaloids present are tested in Uncaria species, on 5-MeO-DMT-induced head-twitch behaviour in reserpinized mice. Neither Rhynchophylline [H=1.369, P=0.504] nor Corynoxeine [H=0.242, P=0.886] affects the behaviour, while Isocorynoxeine significantly attenuates it at 30 mg/kg (i.p.) [H=7.582, P<0.01].
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-N0775 | 异去氢钩藤碱 Isocorynoxeine | 51014-29-0 | 5mg | 1450元 |
| 2024/11/08 | HY-N0775 | Isocorynoxeine | 10 mM * 1 mLin DMSO | 1595元 |