| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-400-6206333 18521732826 |
| Email: |
market@aladdin-e.com |
| Products Intro: |
Product Name:(±)15-HEPE
CAS:88852-33-9
Purity:98%,~100?μg/mL in ethanol Package:25μg/RMB 1999.90;50μg/RMB 3799.90;100μg/RMB 7199.90
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| Company Name: |
Yichang Zhongyitai Trading Co., Ltd.
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| Tel: |
0717-6449896 13886658719 |
| Email: |
root@zhongyitai.com |
| Products Intro: |
Product Name:15-hydroxy-5(Z),8(Z),11(Z),13(E),17(Z)-eicosapentaenoic acid
CAS:88852-33-9
Purity:98+% Package:100ug
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| Company Name: |
Alfa Chemistry
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| Tel: |
1-516-6625404 |
| Email: |
support@alfa-chemistry.com |
| Products Intro: |
Product Name:15-hydroxy-5(Z),8(Z),11(Z),13(E),17(Z)-eicosapentaenoic acid
CAS:88852-33-9
Purity:98%+ Package:1g;10g;100g;1KG;5KG
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| | (+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID Basic information |
| Product Name: | (+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID | | Synonyms: | (+/-)15-HEPE;(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID;(+/-)-15-Hydroxy-5Z,8Z,11Z,13E,17Z-eicosadienoic acid;WLKCSMCLEKGITB-XWJJKCKWSA-N;15-hydroxy-eicosa-5Z,8Z,11Z,13E,17Z-pentaenoic acid;(+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID;5,8,11,13,17-Eicosapentaenoic acid, 15-hydroxy-, (5Z,8Z,11Z,13E,17Z)- | | CAS: | 88852-33-9 | | MF: | C20H30O3 | | MW: | 318.45 | | EINECS: | | | Product Categories: | | | Mol File: | 88852-33-9.mol |  |
| | (+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID Chemical Properties |
| Boiling point | 488.0±45.0 °C(Predicted) | | density | 0.997±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml | | pka | 4.75±0.10(Predicted) |
| | (+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID Usage And Synthesis |
| Description | (±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE . 15(S)-HEPE is formed from EPA via a 15(S)-HpEPE intermediate, which is produced by 15-lipoxygenase (15-LO) and reduced by glutathione peroxidase (GPX).1,2 (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively).3 It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 μM).4 Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.5,6 | | Definition | ChEBI: 15-HEPE is a hydroxyicosapentaenoic acid that consists of 5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid bearing an additional 15-hydroxy substituent. It has a role as a mouse metabolite. It is a HEPE and a hydroxy polyunsaturated fatty acid. | | References | 1. Miller, C., Yamaguchi, R.Y., and Ziboh, V.A. Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids Lipids 24(12),998-1003(1989).
2. Tan, L., Xin, X., Zhai, L., et al. Drosophila fed ARA and EPA yields eicosanoids, 15S-hydroxy-5Z,8Z, 11Z, 13E-eicosatetraenoic acid, and 15S-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid Lipids 51(4),435-449(2016).
3. Desbois, A.P., and Lawlor, K.C. Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus Mar. Drugs 11(11),4544-4557(2013).
4. Lam, B., Marcinkiewicz, E., and Wong, P.Y.-K. Transformation of 15-hydroperoxyeicosapentaenoic acid into mono- and dihydroxyeicosapentaenoic acids by human platelets Drugs affecting leukotrienes and other eicosanoid pathways ,167-180(1985).
5. Lundstr?m, S.L., Yang, J., K?llberg, H.J., et al. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation PLoS One 7(3),e33780(2012).
6. Archambault, A.-S., Zaid, Y., Rakotoarivelo, V., et al. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients FASEB J. 35(6),e21666(2021). |
| | (+/-)-15-HYDROXY-5Z,8Z,11Z,13E,17Z-EICOSAPENTAENOIC ACID Preparation Products And Raw materials |
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