| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:VDM 11;(5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-Methylphenyl)-5,8,11,14-eicosatetraenaMide
CAS:313998-81-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:VDM 11
CAS:313998-81-1
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE Basic information |
| Product Name: | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE | | Synonyms: | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE;N-(4-HYDROXY-2-METHYLPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(4-HYDROXY-2-METHYLPHENYL)ARACHIDONYLAMIDE;N-ARACHIDONOYL-4-HYDROXY-2-METHYLANILIN;N-ARACHIDONYL-4-HYDROXY-2-METHYLANILIN;VDM 11;N-(4-Hydroxy-2-methylphenyl)arachidonylamide, (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide;VDM 11 (in Tocrisolve(TM) 100) | | CAS: | 313998-81-1 | | MF: | C27H39NO2 | | MW: | 409.6 | | EINECS: | | | Product Categories: | Cannabinoid receptor | | Mol File: | 313998-81-1.mol |  |
| | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE Chemical Properties |
| storage temp. | −20°C | | solubility | DMSO: >5 mg/mL, soluble | | form | oil | | color | gold | | Stability: | Light Sensitive |
| | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE Usage And Synthesis |
| Description | Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons. VDM11 is an AEA transport inhibitor with essentially no activity on either the central cannabinoid receptor (CB1), peripheral cannabinoid receptor (CB2), or the vanilloid receptor 1 (VR1). However, VDM11 inhibits FAAH and monoacylglycerol lipase (MAGL) and may act as an alternative FAAH substrate. At a concentration of 3 μM, VDM11, like AM404, inhibits glutamergic synaptic transmission between hippocampal neurons. The mechanism of this effect may be a direct action on sodium channels. Thus, the use of anandamide analogs as uptake inhibitors and interpretation of the results must be undertaken with care. | | Uses | VDM-11 is a selective inhibitor of the anandamide membrane transporter. | | Biological Activity | A potent and selective inhibitor of the anandamide membrane transporter (AMT), in water-soluble emulsion (for details see TocrisolveTM 100). IC 50 values for inhibition of AMT are 4-11 mM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB 1 and CB 2 receptors. K i values are > 5-10 mM at CB 1 and CB 2 . Active in vivo . Also available as pure oil dissolved in ethanol ((5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide ). |
| | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE Preparation Products And Raw materials |
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