那可丁
| 中文名称 | 那可丁 |
|---|---|
| 中文同义词 | 那可汀鹼鹽酸鹽;那可丁盐酸盐;那可汀盐酸盐水合物;那可汀 盐酸盐;诺司卡品 盐酸盐 水合物;6,7-二甲氧基-3-(4-甲氧基-6-甲基-7,8-二氢-5H-[1,3]二氧环戊并[4,5-G]异喹啉-5-基)-3H-2-苯并呋喃-1-酮盐酸盐;盐酸那可丁;盐酸那可汀 |
| 英文名称 | NOSCAPINE HYDROCHLORIDE |
| 英文同义词 | NOSCAPINE HYDROCHLORIDE;NARCOTINE HYDROCHLORIDE;,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-;1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1;1-alpha-narcotinehydrochloride;coscopinhydrochloride;coscotabshydrochloride;key-tusscapinehydrochloride |
| CAS号 | 912-60-7 |
| 分子式 | C22H24ClNO7 |
| 分子量 | 449.88 |
| EINECS号 | 213-014-9 |
| 相关类别 | 中草药成分;小分子抑制剂;有机碱;小分子抑制剂，天然产物;生化试剂;通用生化试剂-天然产物;Inhibitors |
| Mol文件 | 912-60-7.mol |
| 结构式 |  |
那可丁 性质
| 熔点 | 221-223 °C(lit.) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 易溶于水和乙醇（96%）。水溶液呈微酸性；当溶液静置时，遇碱可能会沉淀。 |
| 颜色 | 晶体 |
| Merck | 13,6752 |
| EPA化学物质信息 | 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7) |
Sigma opioid receptors Bradykinin Apoptosis
Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC
50
of 250 μM at 72 hours.
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.
Cell Proliferation Assay
| Cell Line: | Rat C6 glioma cells |
| Concentration: | 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM |
| Incubation Time: | 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours |
| Result: | Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. |
Noscapine (300 mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells |
| Dosage: | 300 mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume. |
安全信息
| 提供商 | 语言 |
|---|---|
|
英文
|
那可丁 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | N0963 | 那可丁盐酸盐 水合物 Noscapine Hydrochloride Hydrate | 912-60-7 | 5g | 1020元 |