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| | [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Basic information |
| Product Name: | [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol | | Synonyms: | [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol;Limacusine;2H-1,24:12,15-Dietheno-6,10-metheno-16H-pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol, 3,4,4a,5,16a,17,18,19-octahydro-9,21,25-trimethoxy-4,17-dimethyl-, (4aR,16aR)- | | CAS: | 10172-03-9 | | MF: | C37H40N2O6 | | MW: | 608.72 | | EINECS: | | | Product Categories: | | | Mol File: | 10172-03-9.mol | ![[1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Structure](CAS/GIF/10172-03-9.gif) |
| | [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Chemical Properties |
| Melting point | 235-7°C | | Boiling point | 709.7±60.0 °C(Predicted) | | density | 1.204±0.06 g/cm3(Predicted) | | pka | 9.38±0.20(Predicted) |
| | [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Usage And Synthesis |
| Description | A second bisbenzylisoquinoline base from Limacia cuspidata (Miers.) Hook. f. et
Thorn., the alkaloid is separated from the accompanying !imacine by chromato?
graphy on a silica column. It crystallizes in colourless prisms from MeOH-Me2 CO
and has [α]D + 110° (CHCI3). One hydroxyl group is present and the alkaloid
yields the O-methyl ether as colourless needles, m.p. 210-2° C; [α]D + 90°,
(CHCI3), shown to be identical with N-methyl-dihydroepistephanine B. The
structure has been established by chemical interconversions with limacine and
cuspidaline (q.v.). | | References | Tomita, Furukawa., Tetrahedron Lett., 4293 (I 966)
Structure:
Tomita, Furukawa, Fukagawa., l. Pharm. Soc., lapan, 87,793 (I967) |
| | [1R,(+)]-6,6',12'-Trimethoxy-2,2'-dimethyloxyacanthan-7-ol Preparation Products And Raw materials |
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