Nimustine manufacturers
- Nimustine USP/EP/BP
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- $1.10 / 1g
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2021-07-06
- CAS:42471-28-3
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Nimustine
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- $1.00 / 1ASSAYS
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2020-01-09
- CAS:42471-28-3
- Min. Order: 1ASSAYS
- Purity: 85.0-99.8%
- Supply Ability: 20tons
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| Nimustine Basic information |
Product Name: | Nimustine | Synonyms: | 1-(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA HYDROCHLORIDE;1-((4-amino-2-methylpyrimidin-5-yl)methyl)-3-(2-chloroethyl)-3-nitrosourea;NIMUSTINE;NIMUSTINE HCL;N'-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-N-(2-CHLORETHYL)-N-NITROSOUREA;ACNU;3-(4-amino-2-methyl-5-pyrimidinyl)methyl-1-(2-chloroethyl)-1-nitrosourea;n’-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(2-chloroethyl)-n-nitroso-ure | CAS: | 42471-28-3 | MF: | C9H13ClN6O2 | MW: | 272.69 | EINECS: | 255-838-1 | Product Categories: | | Mol File: | 42471-28-3.mol | ![Nimustine Structure](CAS/GIF/42471-28-3.gif) |
| Nimustine Chemical Properties |
Melting point | 125°C (rough estimate) | Boiling point | 98°C (rough estimate) | density | 1.9048 (rough estimate) | refractive index | 1.5790 (estimate) | pka | 9.58±0.46(Predicted) | form | solid | CAS DataBase Reference | 42471-28-3(CAS DataBase Reference) |
Hazard Codes | T | Risk Statements | 25 | Safety Statements | 36/37/39-45 | RIDADR | UN 2811 6.1/PG 3 | WGK Germany | 3 | RTECS | YR8450000 |
| Nimustine Usage And Synthesis |
Originator | Nidran,Sankyo,Japan,1979 | Definition | ChEBI: An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-amino-2-methylpyrimidin-5-ylmethyl] group. An anti
eoplastic agent especially effective against malignant brain tumors. | Manufacturing Process | 0.4 g of sodium nitrite was added with stirring, at 0°C to 5°C, to a solution of
450 mg of 1-(2-chloroethyl)-3-[(2-methyl-4-aminopyridin-5-yl)methyl]urea in
8 ml of 5% hydrochloric acid, and the reaction mixture was then stirred at
0°C to 10°C for an additional 1.5 hours. After completion of the reaction, the reaction mixture was made alkaline by
the addition of sodium carbonate, whereupon crystals separated out in situ.
The crystals were recovered by filtration, washed with water and then
recrystallized from 6 ml of ethanol, to give 0.1 g of the pale yellow pure
desired product having a decomposition point of 125°C. | Therapeutic Function | Antitumor, Antileukemic |
| Nimustine Preparation Products And Raw materials |
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