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N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE

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N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Corrector C4；Corr4a;Corr 4a;Corrector C 4;Corr-4a;Corrector C-4
CAS:421580-53-2
Package:10 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: DC Chemicals  
Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Products Intro: Product Name:Corr4A
CAS:421580-53-2
Purity:98% HPLC Package:100mg，250mg，1g
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 13675144456
Email: sean.lv@synzest.com
Products Intro: Product Name:N-5-2-(5-Chloro-2-methoxy-anilino)thiazol-4-yl-4-methyl-thiazol-2-ylbenzamide
CAS:421580-53-2
Purity:95%HPLC Package:500mg;1g;5g;10g
Company Name: Changzhou Bojia Biomedical Technology Co., Ltd.  
Tel: 2122619822
Email: czbjpharma@126.com
Products Intro: CAS:421580-53-2
Purity:98% Package:100mg/1g/10g/100g/1kg
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:Corrector C4
CAS:421580-53-2
Purity:详情请见官网 Package:5 mg;100 mg;50 mg;10 mg;1 mg;500 mg;25 mg;
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Basic information
Product Name:N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
Synonyms:N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE;N-[2-(5-CHLORO-2-METHOXY-PHENYLAMINO)-4'-METHYL-[4,5']BITHIAZOLYL-2'-YL]-BENZAMIDE;N-[5-[2-(5-Chloro-2-methoxy-anilino)thiazol-4-yl]-4-methyl-thiazol-2-yl]benzamide;N-[5-[2-(5-chloro-2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide;Corrector C4;Benzamide, N-[2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-;N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
CAS:421580-53-2
MF:C21H17ClN4O2S2
MW:456.97
EINECS:
Product Categories:
Mol File:421580-53-2.mol
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Structure
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Chemical Properties
density 1.440±0.06 g/cm3(Predicted)
pka6.81±0.70(Predicted)
Safety Information
MSDS Information
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Usage And Synthesis
General DescriptionA cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR ΔF508 mutant via direct interaction and promote proper trafficking/glycosylation and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients, while exhibiting little correcting effect toward N1303K-CFTR, P574H-CFTR, M345T-DRD4 (dopamine receptor 4), or G268V-ABCA1/CD243 /MDR1/ P-gp mutant. Reported to enhance the folding efficiency of both ΔF508 (by 3-fold at 10μM in FRT cells) and wild-type CFTR (by up to 70%), delay the ER-associated degradation of the core-glycosylated ΔF508 (by 30% at 10μM in FRT cells), and increase the stability of low-temperature resuced ΔF508 mutant on the plasma membrane (by 1.7-fold at 10μM in FRT cells). Corr-4a is shown to be more effective than VRT-325/CFcor-325 n restoring forskolin-stimulated CFTR activity in FRT and A549 ΔF508-CFTR transfectants. Unlike VRT-532 Corr-4a does not affect mutant CFTR channel gating activity.
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Preparation Products And Raw materials
Tag:N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE(421580-53-2) Related Product Information
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE