伏环孢素
| 中文名称 | 伏环孢素 |
|---|---|
| 中文同义词 | 化合物 T17235;单孢菌素;挥发性孢子蛋白;伏环孢素;狼疮肾炎;伏环孢素VOCLOSPORIN;沃罗孢素;伏环孢素/沃罗孢素 |
| 英文名称 | Voclosporin |
| 英文同义词 | Isatx 247;Isatx247;Isatx-247;Luveniq;Lx211;R 1524;Voclosporin;Voclosporin [usan] |
| CAS号 | 515814-01-4 |
| 分子式 | C63H111N11O12 |
| 分子量 | 1214.65 |
| EINECS号 | |
| 相关类别 | 多肽抑制剂;医药原料;贝尔卡主打;武汉贝尔卡主打;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;API |
| Mol文件 | 515814-01-4.mol |
| 结构式 |  |
伏环孢素 性质
| 沸点 | 1303.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.016±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 苯（微量）、甲醇（微量） |
| 酸度系数(pKa) | 13.32±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
Calcineurin
This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro.
All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-106638 | Voclosporin | 1 mg | 1700元 | |
| 2024/11/08 | HY-106638 | Voclosporin Voclosporin | 515814-01-4 | 5mg | 4050元 |