7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354 +1-00000000000
Email:	marketing@targetmol.com
Products Intro:	Product Name:7-Chlorokynurenic acid CAS:18000-24-3 Purity:99.72% Package:10mg;37USD\|25mg;77USD\|50mg;147USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Career Henan Chemica Co
Tel:	+86-0371-86658258 +8613203830695
Email:	laboratory@coreychem.com
Products Intro:	Product Name:7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL CAS:18000-24-3 Purity:99% Email: cherry@coreychem.com Package:1g;0.37USD

Company Name:	LEAP CHEM CO., LTD.
Tel:	+86-852-30606658
Email:	market18@leapchem.com
Products Intro:	Product Name:7-Chlorokynurenic acid CAS:18000-24-3 Package:1g; 5g; 25g; 1kg; 5kg; 25kg

Company Name:	Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel:	+86-057181025280; +8617767106207
Email:	sales@molcore.com
Products Intro:	Product Name:7-Chlorokynurenic acid CAS:18000-24-3 Purity:NLT 98% Remarks:MC533051

Company Name:	TargetMol Chemicals Inc.
Tel:
Email:	support@targetmol.com
Products Intro:	Product Name:7-Chlorokynurenic acid CAS:18000-24-3 Purity:99.72% Package:10mg;37USD\|25mg;77USD\|50mg;147USD

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL manufacturers

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Basic information

Product Name:	7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
Synonyms:	7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL;7-CHLOROKYNURENIC ACID;7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-CL-KYNA;7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-Chloroquinurenic acid;7-CKA
CAS:	18000-24-3
MF:	C10H6ClNO3
MW:	223.61
EINECS:	241-913-6
Product Categories:	pharmacetical;Glutamate;Glutamate receptor
Mol File:	18000-24-3.mol

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties

Melting point	277-278 °C (decomp)
Boiling point	461.5±45.0 °C(Predicted)
density	1.600±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	0.1 M NaOH: 13.7 mg/mL
form	solid
pka	0.90±0.30(Predicted)
color	tan
CAS DataBase Reference	18000-24-3(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Usage And Synthesis

Target	Ki: 0.59 μM (reuptake of glutamate) IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)
Uses	NMDA receptor antagonist at the glycine site
Definition	ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Biological Functions	Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
Biological Activity	NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivo	Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
storage	Room temperature

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Preparation Products And Raw materials

Tag:7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL(18000-24-3) Related Product Information

Trichloroisocyanuric acid 5-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL 5,7-DICHLOROKYNURENIC ACID SODIUM SALT 5,7-DICHLORO-4-HYDROXY-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER METHYL 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLATE 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL DICHLOROKYNURENIC ACID, 5,7-[3-3H]-

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