N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Suppliers list

Company Name:	Career Henan Chemica Co
Tel:	+86-0371-86658258 +8613203830695
Email:	laboratory@coreychem.com
Products Intro:	Product Name:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide CAS:211311-95-4 Purity:95.0% windy 112

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:LY-404187 CAS:211311-95-4 Purity:98% Package:5mg Remarks:V12017

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354
Email:	support@targetmol.com
Products Intro:	Product Name:LY-404187；LY404187 CAS:211311-95-4 Package:10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Aladdin Scientific
Tel:	+1-+1(833)-552-7181
Email:	sales@aladdinsci.com
Products Intro:	Product Name:LY 404187 CAS:211311-95-4 Purity:98% Package:$23.9/1mg;$98.9/5mg;$167.9/10mg;$756.9/50mg;$1360.9/100mg;Bulk package Remarks:98%

Company Name:	Amadis Chemical Company Limited
Tel:	571-89925085
Email:	sales@amadischem.com
Products Intro:	Product Name:N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide CAS:211311-95-4 Purity:0.97 Package:mgs,gs,kgs Remarks:A879241

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Basic information

Product Name:	N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
Synonyms:	N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;LY404187;N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;CS-2739;100775
CAS:	211311-95-4
MF:	C19H22N2O2S
MW:	342.46
EINECS:
Product Categories:
Mol File:	211311-95-4.mol

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemical Properties

Boiling point	519.0±60.0 °C(Predicted)
density	1.19±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form	A solid
pka	11.24±0.40(Predicted)
color	White to off-white

Safety Information

MSDS Information

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Usage And Synthesis

Description	LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1_i, -2_i, -2_o, -3_i, and -4_i subunit-containing AMPA receptors with EC₅₀ values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC₅₀s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.
Uses	LY 404187 is a novel positive allosteric modulator of AMPA receptors.
storage	Store at +4°C

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Preparation Products And Raw materials

Tag:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide(211311-95-4) Related Product Information

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