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| N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Basic information |
Product Name: | N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide | Synonyms: | N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;LY404187;N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;CS-2739;100775 | CAS: | 211311-95-4 | MF: | C19H22N2O2S | MW: | 342.46 | EINECS: | | Product Categories: | | Mol File: | 211311-95-4.mol | ![N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Structure](CAS/GIF/211311-95-4.gif) |
| N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemical Properties |
Boiling point | 519.0±60.0 °C(Predicted) | density | 1.19±0.1 g/cm3(Predicted) | storage temp. | Sealed in dry,Room Temperature | solubility | DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL | form | A solid | pka | 11.24±0.40(Predicted) | color | White to off-white |
| N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Usage And Synthesis |
Description | LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day. | Uses | LY 404187 is a novel positive allosteric modulator of AMPA receptors. | storage | Store at +4°C |
| N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Preparation Products And Raw materials |
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