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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:LY-404187
CAS:211311-95-4
Purity:99.34% Package:5mg;48USD|10mg;83USD|25mg;167USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
CAS:211311-95-4
Purity:95.0% windy 112
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:LY-404187
CAS:211311-95-4
Purity:98% Package:5mg Remarks:V12017
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:LY-404187；LY404187
CAS:211311-95-4
Package:10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:LY 404187
CAS:211311-95-4
Purity:98% Package:$23.9/1mg;$98.9/5mg;$167.9/10mg;$756.9/50mg;$1360.9/100mg;Bulk package Remarks:98%

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide manufacturers

  • LY-404187
  • LY-404187 pictures
  • $48.00 / 5mg
  • 2024-11-17
  • CAS:211311-95-4
  • Min. Order:
  • Purity: 99.34%
  • Supply Ability: 10g
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Basic information
Product Name:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
Synonyms:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;LY404187;N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;CS-2739;100775
CAS:211311-95-4
MF:C19H22N2O2S
MW:342.46
EINECS:
Product Categories:
Mol File:211311-95-4.mol
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Structure
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemical Properties
Boiling point 519.0±60.0 °C(Predicted)
density 1.19±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form A solid
pka11.24±0.40(Predicted)
color White to off-white
Safety Information
MSDS Information
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Usage And Synthesis
DescriptionLY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.
UsesLY 404187 is a novel positive allosteric modulator of AMPA receptors.
storageStore at +4°C
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Preparation Products And Raw materials
Tag:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide(211311-95-4) Related Product Information
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