Q-VD-OPh hydrate manufacturers
- Q-VD-OPh hydrate
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- $1.00 / 1g
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2019-12-20
- CAS:1135695-98-5
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 2tons
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| | Q-VD-OPh hydrate Basic information |
| Product Name: | Q-VD-OPh hydrate | | Synonyms: | Q-VD-OPh hydrate;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate;Quinoline-Val-Asp-Difluorophenoxymethylketone);CS-2734;Q-VD-OPh (QVD-OPH;QVD-OPH;QUINOLINE-VAL-ASP-DIFLUOROPHENOXYMETHYLKETONE;Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)- | | CAS: | 1135695-98-5 | | MF: | C26H25F2N3O6 | | MW: | 513.49 | | EINECS: | | | Product Categories: | Apoptosis | | Mol File: | 1135695-98-5.mol |  |
| | Q-VD-OPh hydrate Chemical Properties |
| Boiling point | 808.9±65.0 °C(Predicted) | | density | 1.346±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | -20°C | | solubility | DMSO: ≥14mg/mL | | pka | 3.92±0.19(Predicted) | | form | powder | | color | white to light brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | InChIKey | OOBJCYKITXPCNS-REWPJTCUSA-N |
| | Q-VD-OPh hydrate Usage And Synthesis |
| Description | Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 μM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK . Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis. This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer. | | Uses | An inhibitor that is used in Alzheimer’s studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor. | | Uses | Q-VD-OPh hydrate has been used:
- as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
- to induce canonical caspase-dependent apoptosis in UC cells
- to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
- to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells
| | Biochem/physiol Actions | Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone. | | target | caspase-1 | | storage | +4°C | | References | 1) Caserta?et al.?(2003),?Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis,?8?345
2) Braun?et al.?(2007),?Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol.,?206?183
3) Rebbaa?et al.?(2003),?Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene,?22?2805
4) Bulatovic?et al.?(2015),?Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One,?10?e0120176
5) Bailey?et al. (2017),?Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis;?Cell Death Dis.,?8?e2590 |
| | Q-VD-OPh hydrate Preparation Products And Raw materials |
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