- (R)-Niraparib
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- $0.00 / 10mg
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2024-05-07
- CAS:1038915-58-0
- Min. Order: 10mg
- Purity: 0.98
- Supply Ability: 10g
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| | MK-4827 (R-enantioMer) Basic information |
| Product Name: | MK-4827 (R-enantioMer) | | Synonyms: | MK-4827 (R-enantioMer);Niraparib Impurity;R isomer of MK-4827, Niraparib;(R)-2-(4-(PIPERIDIN-3-YL)PHENYL)-2H-INDAZOLE-7-CARBOXAMIDE;Niraparib R-enantiomer;2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide;ent-Niraparib;2H-Indazole-7-carboxamide, 2-[4-(3R)-3-piperidinylphenyl]- | | CAS: | 1038915-58-0 | | MF: | C19H20N4O | | MW: | 320.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1038915-58-0.mol |  |
| | MK-4827 (R-enantioMer) Chemical Properties |
| Boiling point | 463.6±45.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 32 mg/mL (99.88 mM) | | pka | 15.36±0.30(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | MK-4827 (R-enantioMer) Usage And Synthesis |
| Uses | ent-Niraparib is an isomer of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. | | Definition | ChEBI: 2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has R-configuration. It is a potent PARP1 inhibitor with IC50 of 2.4 nM. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an antineoplastic agent. |
| | MK-4827 (R-enantioMer) Preparation Products And Raw materials |
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