|
|
| | HuangjiangSu A Basic information |
| Product Name: | HuangjiangSu A | | Synonyms: | (3beta,25R)-26-(beta-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranoside;HuangjiangSu A;β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]- | | CAS: | 1026020-27-8 | | MF: | C51H82O22 | | MW: | 1047.2 | | EINECS: | | | Product Categories: | | | Mol File: | 1026020-27-8.mol |  |
| | HuangjiangSu A Chemical Properties |
| Melting point | 274-276 °C | | density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 12?+-.0.70(Predicted) |
| | HuangjiangSu A Usage And Synthesis |
| Description | Huangjiangsu A is a natural active ingredient found in many plants such as Dioscorea villosa and Polygonatum multiflorum. It belongs to the steroidal saponin class of compounds. Huangjiangsu A is not cytotoxic, and treatment of HepG2 cells with it prior to exposure to H2O2 was effective in increasing cell viability in a concentration-dependent manner. In addition, 50 μM of Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin increased GSH levels and reduced intracellular ROS production, thereby counteracting H2O2-induced injury. Thus, Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation, and is expected to be a potential drug for the treatment of liver diseases[1-2]. | | References | [1] MAQSOOD A SIDDIQUI. Hepatoprotective Effect of Steroidal Glycosides From Dioscorea villosa on Hydrogen Peroxide-Induced Hepatotoxicity in HepG2 Cells.[J]. Frontiers in Pharmacology, 2018. DOI:10.3389/fphar.2018.00797.
[2] LILI GVAZAVA . New furostanol glycosides from Polygonatum multiflorum (L.) All.[J]. Natural Product Research, 2019. DOI:10.1080/14786419.2018.1431628.
|
| | HuangjiangSu A Preparation Products And Raw materials |
|