1502816-23-0
| 中文名称 | 1502816-23-0 |
|---|---|
| 中文同义词 | PRMT4和PRMT6双重抑制剂(MS049);化合物MS049;2-(4-(苄氧基)哌啶-1-基)-N-甲基乙胺 |
| 英文名称 | MS049 |
| 英文同义词 | MS049;MS049 2HCl;2-[4-(benzyloxy)piperidin-1-yl]ethyl}(methyl)amine;MS049;MS-049;MS 049;1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)-;2-(4-(Benzyloxy)piperidin-1-yl)-N-methylethanamine;MS049 diHCl;MS-049,arginine,Histone Methyltransferase,MS 049,HEK293,dimethylation,Inhibitor,toxic,H4R3me2a,MS049,inhibit,selective,epigenetic,cells,modifiers |
| CAS号 | 1502816-23-0 |
| 分子式 | C15H24N2O |
| 分子量 | 248.36 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1502816-23-0.mol |
| 结构式 |  |
1502816-23-0 性质
| 沸点 | 352.6±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.03±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥31mg/mL（124.82mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.48±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
MS049 是一种高效、选择性和细胞活性的 PRMT4 和 PRMT6 双重抑制剂，IC50 分别为 34 nM 和 43 nM。MS049 降低了 HEK293 细胞的 Med12me2a 和 H3R2me2a 水平。MS049 对 HEK293 细胞无毒，并且没有影响其的生长。
IC50: 34 nM (PRMT4), 43 nM (PRMT6)
MS049 (0.1-10 μM; 20 hours) reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC
50
=0.97±0.05 μM).
MS049 (0.1-100 μM; 72 hours) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC
50
=1.4±0.1 μM) in HEK293 cells.
MS049 is selective for PRMT4 and PRMT6 over a broad range of epigenetic modifiers, including other PRMTs, PKMTs, DNMTs, KDMs, and methyllysine/methylarginine reader proteins, and non-epigenetic targets.
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 0.1, 1, 10 μM |
| Incubation Time: | 20 hours |
| Result: | Reduced the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC 50 =0.97±0.05 μM). |
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 0.1, 1, 10, 100 μM |
| Incubation Time: | 72 hours |
| Result: | Reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC 50 =1.4±0.1 μM) in HEK293 cells. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100360 | 1502816-23-0 MS049 | 1502816-23-0 | 5mg | 660元 |
| 2024/04/30 | HY-100360 | 1502816-23-0 MS049 | 1502816-23-0 | 10mM * 1mLin DMSO | 726元 |