3-羟基-2-吡咯烷酮
| 中文名称 | 3-羟基-2-吡咯烷酮 |
|---|---|
| 中文同义词 | BAY41-4109外消旋酒石酸盐;4-(2-氯-4-氟苯基)-2-(3,5-二氟吡啶-2-基)-6-甲基-1,4-二氢嘧啶-5-羧酸甲酯 |
| 英文名称 | BAY41-4109 Racemic |
| 英文同义词 | BAY41-4109 Racemic;Bay 41-4109 (racemate);Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate;BAY41-4109 RACEMATE; BAY-41-4109 RACEMATE;5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester;4-?(2-Chloro-?4-?fluorophenyl)?-?2-?(3,?5-?difluoro-?2-?pyridinyl)?-?1,?4-?dihydro-?6-?methyl-?5-?pyrimidinecarboxylic Acid Methyl Ester;Bay 41-4109,Inhibitor,HBV,Bay 41 4109 racemate,inhibit,Bay 414109 racemate,Hepatitis B virus |
| CAS号 | 298708-79-9 |
| 分子式 | C18H13ClF3N3O2 |
| 分子量 | 395.76 |
| EINECS号 | |
| 相关类别 | API |
| Mol文件 | 298708-79-9.mol |
| 结构式 |  |
3-羟基-2-吡咯烷酮 性质
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
|---|---|
| 溶解度 | DMSO:89.5(最大浓度 mg/mL);226.14(最大浓度 mM) 乙醇:11.0(最大浓度 mg/mL);27.79(最大浓度 mM) |
| 形态 | 结晶固体 |
| 颜色 | 浅黄至黄色 |
| Target | Value |
|
HBV capsid
(Cell-free assay) | 53 nM |
BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro . Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC 50 s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100029A | Bay 41-4109 racemate | 1 mg | 266元 | |
| 2024/04/30 | HY-100029A | 3-羟基-2-吡咯烷酮 Bay 41-4109 racemate | 298708-79-9 | 5mg | 700元 |