1-(4-氯苯基)-3-(5-异丙基-1-甲基-3-氧亚基-2-苯基-2,3-二氢-1H-吡唑-4-基)脲
| 中文名称 | 1-(4-氯苯基)-3-(5-异丙基-1-甲基-3-氧亚基-2-苯基-2,3-二氢-1H-吡唑-4-基)脲 |
|---|---|
| 中文同义词 | 1-(4-氯苯基)-3-(5-异丙基-1-甲基-3-氧亚基-2-苯基-2,3-二氢-1H-吡唑-4-基)脲;化合物 T17005;FPR激动剂43;TC-FPR 43,FPR2激动剂 |
| 英文名称 | 1-(4-Chlorophenyl)-3-(5-Isopropyl-1-Methyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazol-4-Yl)Urea |
| 英文同义词 | 1-(4-Chlorophenyl)-3-(5-Isopropyl-1-Methyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazol-4-Yl)Urea;1-(4-Chlorophenyl)-3-(5-Isopropyl-1-Methyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazol-4-Yl)Urea(WXC04969);N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea;TC-FPR 43;Urea, N-(4-chlorophenyl)-N'-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]- |
| CAS号 | 903895-98-7 |
| 分子式 | C20H21ClN4O2 |
| 分子量 | 384.86 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 903895-98-7.mol |
| 结构式 |  |
1-(4-氯苯基)-3-(5-异丙基-1-甲基-3-氧亚基-2-苯基-2,3-二氢-1H-吡唑-4-基)脲 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMF：5mg/mL； DMF:PBS (pH 7.2) (1:5)：0.16 mg/mL；二甲基亚砜：1mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 白色至浅黄色 |
FPR Agonist 43 (compound 43) 是有效的甲酰基肽受体 1 (FPR1) 和甲酰基肽受体 2 (FPR2)/ALX 双重激动剂。
FPR1, FPR2/ALX
FPR Agonist 43 (10
-5
-10
7
nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells.
FPR Agonist 43 is also active in the GTPγ binding assay (IC
50
=207±51 nM).
FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells.
Cell Viability Assay
| Cell Line: | Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors |
| Concentration: | 10 -5 , 10 -3 , 0.1, 10, 1000, 10 5 , 10 7 nM |
| Incubation Time: | |
| Result: | Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC 50 =11.6±1.9 nM). |