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| | Methyl 2,4-dichloropyrimidine-6-carboxylate Basic information |
| | Methyl 2,4-dichloropyrimidine-6-carboxylate Chemical Properties |
| Melting point | 54-56 | | Boiling point | 306 ºC | | density | 1.503 | | Fp | 139 ºC | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | White to off white to faint cream flakes | | pka | -5.83±0.30(Predicted) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933599590 |
| | Methyl 2,4-dichloropyrimidine-6-carboxylate Usage And Synthesis |
| Synthesis | To a stirred suspension of orotic acid (20.00 g, 128.140 mmol) in POCI3(75 ml) was added DMF (catalytic amount, -0.5 ml) at ambient temperature, and the resulting reaction mixture was refluxed for 3 h. Excess of POC was removed by vacuum distillation after 3h of reflux. The obtained slurry was poured slowly into a 5 per cent mixture of methanol in chloroform (200 ml) at 0°C and stirred for 30 min. The organic layer obtained was washed with a saturated solution of NaHCC>3 (3 x 200 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure, yielding Methyl 2,4-dichloropyrimidine-6-carboxylate (19.00 g, 91 .800 mmol). |
| | Methyl 2,4-dichloropyrimidine-6-carboxylate Preparation Products And Raw materials |
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