- Yangonin
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- $0.00 / 5mg
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2023-02-24
- CAS:500-62-9
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- YANGONIN
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- $1.00 / 1kg
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2019-07-06
- CAS: 500-62-9
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100KG
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| YANGONIN Basic information | Uses |
Product Name: | YANGONIN | Synonyms: | YANGONIN;11-METHOXYYANGONIN;4-methoxy-6-(beta-(p-anisyl)vinyl)-alpha-pyrone;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-on;4-methoxy-6-(p-methoxystyryl)-2h-pyran-2-one;5-hydroxy-3-methoxy-7-(p-methoxyphenyl)-2,4,6-heptatrienoicacidgamma-lacton;4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one;4-Methoxy-6-[(E)-2-(4-methoxyphenyl)vinyl]-2H-pyran-2-one | CAS: | 500-62-9 | MF: | C15H14O4 | MW: | 258.27 | EINECS: | | Product Categories: | Aromatics;Heterocycles;Mutagenesis Research Chemicals | Mol File: | 500-62-9.mol | ![YANGONIN Structure](CAS/GIF/500-62-9.gif) |
| YANGONIN Chemical Properties |
Melting point | 155-157° | Boiling point | 487.6±45.0 °C(Predicted) | density | 1.325 g/cm3 | storage temp. | 2-8°C | solubility | Chloroform (Slightly), Methanol (Slightly) | form | Solid | color | Pale Yellow to Pale Green | BRN | 230710 | Stability: | Light Sensitive | LogP | 1.750 (est) |
| YANGONIN Usage And Synthesis |
Uses | A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. | Description | Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 μM. Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 μM, but whether it serves as an agonist or antagonist at this receptor remains to be determined. Yangonin blocks the activation of NF-κB by TNF-α. It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL). | Uses | A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. | Uses | A lactone isolated from the Kava plant (Piper methysticum).
rokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety d
isorders.
a supplements. | Definition | ChEBI: Yangonin is a member of 2-pyranones and an aromatic ether. |
| YANGONIN Preparation Products And Raw materials |
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