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| | H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH Basic information |
| Product Name: | H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH | | Synonyms: | DYNORPHIN A (1-10) SYNTHETIC >97% OPIOID AGONIST;dynorphin A fragment 1-10 porcine*sequence;DYNORPHIN A (1-10), PORCINE;DYNORPHIN A (1-10);H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH;dynorphin A, porcine, fragment 1-10;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO;YGGFLRRIRP | | CAS: | 79994-24-4 | | MF: | C57H91N19O12 | | MW: | 1234.45 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 79994-24-4.mol |  |
| | H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH Chemical Properties |
| storage temp. | -15°C | | solubility | Soluble in DMSO |
| | H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH Usage And Synthesis |
| Uses | Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM. | | IC 50 | NMDA Receptor; κ Opioid Receptor/KOR | | References | [1] Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62. DOI:10.1021/jm970252j
[2] Chen L, et al. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length. J Pharmacol Exp Ther. 1998 Mar;284(3):826-31. PMID:9495839 |
| | H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH Preparation Products And Raw materials |
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