Porcupine-IN-1
| 中文名称 | Porcupine-IN-1 |
|---|---|
| 中文同义词 | N-((3-氟-2'-甲基-[2,4'-联吡啶]-5-基)甲基)-9H-咔唑-2-甲酰胺;化合物PORCUPINE-IN-1 |
| 英文名称 | Porcupine-IN-1 |
| 英文同义词 | Porcupine-IN-1;PORCN-IN-1;Porcn inhibitor 1;CS-2802;9H-Carbazole-2-carboxamide, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-;Porcupine-IN-1 free base;Porcupine,inhibit,PorcnIN1,Inhibitor,Porcn IN 1 |
| CAS号 | 2036044-77-4 |
| 分子式 | C25H19FN4O |
| 分子量 | 410.44 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2036044-77-4.mol |
| 结构式 |  |
Porcupine-IN-1 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMF：10mg/mL； DMSO：10mg/mL； DMSO:PBS (pH 7.2) (1:1)：0.5 mg/ml；乙醇：微溶 |
| 形态 | 结晶固体 |
| 颜色 | 白色至米白色 |
Porcn-IN-1 是有效的 porcupine 抑制剂，IC50 值为 0.5±0.2 nM。
IC50: 0.5±0.2 nM (Porcupine inhibitor)
Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor.
Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-111472 | Porcn-IN-1 | 1 mg | 681元 | |
| 2024/04/30 | HY-111472 | Porcupine-IN-1 Porcn-IN-1 | 2036044-77-4 | 5mg | 1500元 |