Porcupine-IN-1
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- CAS号:
- 2036044-77-4
- 英文名:
- Porcupine-IN-1
- 英文别名:
- CS-2802;PORCN-IN-1;Porcupine-IN-1;Porcn inhibitor 1;Porcupine-IN-1 free base;Porcupine,inhibit,PorcnIN1,Inhibitor,Porcn IN 1;9H-Carbazole-2-carboxamide, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-
- 中文名:
- Porcupine-IN-1
- 中文别名:
- 化合物PORCUPINE-IN-1;N-((3-氟-2'-甲基-[2,4'-联吡啶]-5-基)甲基)-9H-咔唑-2-甲酰胺
- CBNumber:
- CB44204130
- 分子式:
- C25H19FN4O
- 分子量:
- 410.44
- MOL File:
- 2036044-77-4.mol
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Porcupine-IN-1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: slightly soluble
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形态:
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A crystalline solid
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颜色:
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White to off-white
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Porcupine-IN-1性质、用途与生产工艺
Porcn-IN-1 是有效的 porcupine 抑制剂，IC50 值为 0.5±0.2 nM。
IC50: 0.5±0.2 nM (Porcupine inhibitor)
Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor.
Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg).
Porcupine-IN-1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-111472 | Porcn-IN-1 | | 1 mg | 681元 |
| 2024/04/30 | HY-111472 | Porcupine-IN-1
Porcn-IN-1 | 2036044-77-4 | 5mg | 1500元 |
2036044-77-4, Porcupine-IN-1 相关搜索:
- 药靶配体
- 化合物PORCUPINE-IN-1
- N-((3-氟-2'-甲基-[2,4'-联吡啶]-5-基)甲基)-9H-咔唑-2-甲酰胺
- 2036044-77-4
- Porcupine,inhibit,PorcnIN1,Inhibitor,Porcn IN 1
- Porcupine-IN-1 free base
- 9H-Carbazole-2-carboxamide, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-
- CS-2802
- Porcn inhibitor 1
- PORCN-IN-1
- Porcupine-IN-1