Porcupine-IN-1
- CAS No.
- 2036044-77-4
- Chemical Name:
- Porcupine-IN-1
- Synonyms
- CS-2802;PORCN-IN-1;Porcupine-IN-1;Porcn inhibitor 1;Porcupine-IN-1 free base;Porcn-IN-1, 10 mM in DMSO;Porcupine,inhibit,PorcnIN1,Inhibitor,Porcn IN 1;N-((3-Fluoro-2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide;9H-Carbazole-2-carboxamide, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-
- CBNumber:
- CB44204130
- Molecular Formula:
- C25H19FN4O
- Molecular Weight:
- 410.44
- MDL Number:
- MOL File:
- 2036044-77-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Porcupine-IN-1 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25834 | Porcupine-IN-1 ≥98% | 2036044-77-4 | 1mg | $75 | 2024-03-01 | Buy |
| Cayman Chemical | 25834 | Porcupine-IN-1 ≥98% | 2036044-77-4 | 5mg | $281 | 2024-03-01 | Buy |
| Cayman Chemical | 25834 | Porcupine-IN-1 ≥98% | 2036044-77-4 | 10mg | $488 | 2024-03-01 | Buy |
| Cayman Chemical | 25834 | Porcupine-IN-1 ≥98% | 2036044-77-4 | 25mg | $938 | 2024-03-01 | Buy |
| ChemScene | CS-0041562 | Porcn-IN-1 99.08% | 2036044-77-4 | 10mg | $250 | 2021-12-16 | Buy |
Porcupine-IN-1 Chemical Properties,Uses,Production
Description
Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays). It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 μM, indicating inhibition of porcupine, an enzyme that catalyzes palmitoylation of Wnt proteins.
Uses
Porcupine-IN-1, is a potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
in vivo
Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg)[1].
Porcupine-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4613 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2991 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |