雷弗霉素 A
中文名称 | 雷弗霉素 A |
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中文同义词 | 雷弗霉素 A;雷弗霉素A REVEROMYCIN A |
英文名称 | REVEROMYCIN A |
英文同义词 | REVEROMYCIN A;ZESGNAJSBDILTB-OXVOKJAASA-N;Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester |
CAS号 | 134615-37-5 |
分子式 | C36H52O11 |
分子量 | 660.79 |
EINECS号 | |
相关类别 | 微生物代谢物;Epidermal Growth Factor Receptor (EGFR)Antibiotics;Interferes with Protein Synthesis;Antibiotics;Antibiotics A to;Antineoplastic and Immunosuppressive AntibioticsReceptor Tyrosine Kinase Biology;Antibiotics by Application;Antibiotics N-SAntibiotics;AntifungalAntibiotics;Mechanism of Action;Receptor Tyrosine Kinase Inhibitors;Spectrum of Activity |
Mol文件 | 134615-37-5.mol |
结构式 |
雷弗霉素 A 性质
沸点 | 849.0±65.0 °C(Predicted) |
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密度 | 1.21±0.1 g/cm3(Predicted) |
储存条件 | −20°C |
溶解度 | 在DMF中可溶 |
形态 | 固体 |
酸度系数(pKa) | 4.36±0.17(Predicted) |
颜色 | 棕褐色 |
Reveromycin A inhibits protein synthesis in osteoclasts (OCs) by selectively blocking enzymatic activity of isoleucyl-tRNA synthetase.
Reveromycin A (0.3-30 μM; for 24 h) induces apoptosis in OCs through inhibition of protein synthesis.
Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-129337 | 雷弗霉素 A Reveromycin A | 134615-37-5 | 1 mg | 18200元 |