Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:IMMepip, DihydrobroMide CAS:164391-47-3 Package:100Mg,10Mg
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Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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Tel: |
821-50328103-801 18930552037 |
Email: |
3bsc@sina.com |
Products Intro: |
Product Name:IMMepip dihydrobroMide;4-(1H-IMidazol-4-ylMethyl)piperidinedihydrobroMide CAS:164391-47-3 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Company Name: |
SynAsst Chemical.
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Tel: |
021-60343070 |
Email: |
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Products Intro: |
Product Name:4-((1H-IMidazol-4-yl)Methyl)piperidine dihydrobroMide CAS:164391-47-3 Purity:96%Min Package:10g 100g 500g
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| 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Basic information |
| 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Chemical Properties |
Melting point | 234-235℃ | storage temp. | 2-8°C | solubility | H2O: 7 mg/mL at <40 °C | form | solid | color | light tan | Water Solubility | Soluble to 100 mM in water |
Hazard Codes | Xn | Risk Statements | 22 | WGK Germany | 3 |
| 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Usage And Synthesis |
Description | Immepip is a histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor). It is selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor). Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats. It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg. | Chemical Properties | Crystalline Solid | Uses | A selective nonchiral histamine H3 agonist. | Biological Activity | Potent histamine H 3 receptor agonist. Also binds to H 4 receptors (K i values are 0.4 and 9 nM at human recombinant H 3 and H 4 receptors respectively). Equipotent to or slightly more active than (R)- α -methylhistamine at H 3 receptors. | storage | Desiccate at RT |
| 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Preparation Products And Raw materials |
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