N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺
| 中文名称 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 |
|---|---|
| 中文同义词 | N-(3-DIBENZOFURANYL)-5-NITRO-2-FURANCARBOXAMIDE;STING抑制剂C-178;N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺;化合物C-178 |
| 英文名称 | N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide |
| 英文同义词 | N-(dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide;C-178;N-(3-Dibenzofuranyl)-5-nitro-2-furancarboxamide;2-Furancarboxamide, N-3-dibenzofuranyl-5-nitro-;MITA,inhibit,Inhibitor,STING,MPYS,C178,ERIS,C-178,C 178,Stimulator of Interferon Genes,TMEM173 |
| CAS号 | 329198-87-0 |
| 分子式 | C17H10N2O5 |
| 分子量 | 322.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 329198-87-0.mol |
| 结构式 | ![N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 结构式](CAS/20200119/GIF/329198-87-0.gif) |
N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 性质
| 熔点 | >225°C (dec.) |
|---|---|
| 沸点 | 448.3±35.0 °C(Predicted) |
| 密度 | 1.506±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于DMSO（高达25mg/ml） |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.35±0.43(Predicted) |
| 颜色 | 橙色 |
| 稳定性 | 可在-20°C的DMSO中的溶液下储存长达3个月。 |
| Target | Value |
|
STING
() |
C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells.C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts.
Western Blot Analysis
| Cell Line: | Mouse bone marrow-derived macrophages (BMDMs) |
| Concentration: | 0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM |
| Incubation Time: | 1 hour |
| Result: | Inhibited CMA-induced p-TBK1 expression as a does dependent manner. |
RT-PCR
| Cell Line: | Mouse bone marrow-derived macrophages (BMDMs) |
| Concentration: | 1 μM |
| Incubation Time: | 1 hour |
| Result: | Downregulated Ifnb1 expression in BMDMs. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | S6667 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 STING inhibitor C-178 | 329198-87-0 | 2mg | 1700.35元 |
| 2024/11/08 | S6667 | N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺 STING inhibitor C-178 | 329198-87-0 | 5mg | 2370元 |