氢化可的松琥珀酸酯
| 中文名称 | 氢化可的松琥珀酸酯 |
|---|---|
| 中文同义词 | 氢化可的松琥珀酸酯;氢化可的松半琥珀酸酯;氢可琥珀酸酯;琥珀酸氢化可的松;氢化可的松琥珀酸酯 1G;氢化可的松 21-半琥珀酸酯;氢化可的松半瑚珀酸酯;氢化可的松-21-琥珀酸酯 |
| 英文名称 | Hydrocortisone 21-hemisuccinate |
| 英文同义词 | hydrocortisone 21-(hydrogen succinate);hydrocortisone 21-hemisuccinate*free acid;11β,17α,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate;HYDROCORTISONEHEMISUCCINATE(ANHYDROUS);Cortisol, 21-(hydrogen succinate) (8CI);Cortisol, hydrogen succinate (7CI);NSC 7576;Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β)- |
| CAS号 | 2203-97-6 |
| 分子式 | C25H34O8 |
| 分子量 | 462.53 |
| EINECS号 | 218-612-3 |
| 相关类别 | 激素及有关药物;医药与生物化工;医药原料药;合成;医用原料;标准品;中药对照品;化学试剂;Steroid and Hormone;Steroids |
| Mol文件 | 2203-97-6.mol |
| 结构式 |  |
氢化可的松琥珀酸酯 性质
| 熔点 | 170～172℃ |
|---|---|
| 比旋光度 | [α]D20 +147～+153° (c=1, C2H5OH) (After Drying) |
| 沸点 | 685.5±55.0 °C(Predicted) |
| 密度 | 1.33±0.1 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 几乎不溶于水，易溶于丙酮和无水乙醇。溶于碱金属碳酸盐和碱金属氢氧化物的稀溶液。 |
| 形态 | 固体 |
| 酸度系数(pKa) | pKa 5.10/5.64(20% aq EtOH/50% aq EtOH) (Uncertain) |
| 颜色 | 白色至类白色 |
氢化可的松琥珀酸酯是一种皮质类固醇，用作分析和色谱试剂。
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate)，一种糖皮质激素， 是口服活性的甾体抗炎剂 (SAID)。Hydrocortisone hemisuccinate 抑制 IL-6 和 IL-3 的生物活性，IC50 值分别为 6.7 和 21.4 μM。Hydrocortisone hemisuccinate 可用于溃疡性结肠炎 (UC) 的研究。|
IL-6 6.7 μM (IC 50 ) |
IL-3 21.4 μM (IC 50 ) |
Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC
50
s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.
Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.
Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.
| Animal Model: | Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis |
| Dosage: | 30 mg/kg |
| Administration: | P.o. twice daily for 5 days |
| Result: |
Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight. |
用途
用作医药中间体安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS号 | TU5010147 |
| 提供商 | 语言 |
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英文
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