| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:BT-13
CAS:924537-98-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Product Name: | BT-13 | | Synonyms: | 319H6;BT-13
(RET agonist BT13);BT 13 NEW;Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-;BT-13;RET,Inhibitor,BT-13,inhibit,BT13,BT 13;N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide | | CAS: | 924537-98-4 | | MF: | C23H27F4N3O4S | | MW: | 517.54 | | EINECS: | | | Product Categories: | | | Mol File: | 924537-98-4.mol |  |
| | BT-13 Chemical Properties |
| Boiling point | 637.0±65.0 °C(Predicted) | | density | 1.326±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 25 mg/mL (48.31 mM) | | pka | 0.42±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | BT-13 Usage And Synthesis |
| Biological Activity | BT-13 is a potent, selective agonist of the glial cell-derived neurotrophic factor (GDNF) receptor RET (acts independently of GDNF ligands), promotes sensory neuron neurite outgrowth in vitro, and alleviates neuropathy in rats happened. | | in vitro | BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET. < b> | | in vivo | BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy. | Animal Model: | Rats induced by ligation of left L5 and L6 spinal nerves. | | Dosage: | 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. | | Administration: | Subcutaneous injections on post-surgical days 1, 3, 5, 8, 10, and 12. | | Result: | 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia. | | | target | |
| | BT-13 Preparation Products And Raw materials |
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