BT-13
| 中文名称 | BT-13 |
|---|---|
| 中文同义词 | 化合物BT-13;N,N-二乙基-3-(4-(4-氟-2-(三氟甲基)苯甲酰基)哌嗪-1-基)-4-甲氧基苯磺酰胺 |
| 英文名称 | BT-13 |
| 英文同义词 | 319H6;BT-13 (RET agonist BT13);BT 13 NEW;Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-;BT-13;RET,Inhibitor,BT-13,inhibit,BT13,BT 13;N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide |
| CAS号 | 924537-98-4 |
| 分子式 | C23H27F4N3O4S |
| 分子量 | 517.54 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 924537-98-4.mol |
| 结构式 |  |
BT-13 性质
| 沸点 | 637.0±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.326±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：25 mg/mL（48.31 mM） |
| 酸度系数(pKa) | 0.42±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
BT-13 是有效的、胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂 (独立于 GDNF 配体发挥作用)，促进体外感觉神经元神经突生长，减轻大鼠神经病变的发生。
GDNF receptor RET.
BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.
BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.
| Animal Model: | Rats induced by ligation of left L5 and L6 spinal nerves. |
| Dosage: | 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. |
| Administration: | Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12. |
| Result: | 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia. |