BT-13
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- CAS号:
- 924537-98-4
- 英文名:
- BT-13
- 英文别名:
- 319H6;BT-13;BT 13 NEW;BT-13
(RET agonist BT13);RET,Inhibitor,BT-13,inhibit,BT13,BT 13;N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide;Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-
- 中文名:
- BT-13
- 中文别名:
- 化合物BT-13;N,N-二乙基-3-(4-(4-氟-2-(三氟甲基)苯甲酰基)哌嗪-1-基)-4-甲氧基苯磺酰胺
- CBNumber:
- CB44840103
- 分子式:
- C23H27F4N3O4S
- 分子量:
- 517.54
- MOL File:
- 924537-98-4.mol
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BT-13化学性质
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沸点:
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637.0±65.0 °C(Predicted)
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密度:
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1.326±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 25 mg/mL (48.31 mM)
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酸度系数(pKa):
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0.42±0.20(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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BT-13性质、用途与生产工艺
BT-13 是有效的、胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂 (独立于 GDNF 配体发挥作用)，促进体外感觉神经元神经突生长，减轻大鼠神经病变的发生。
BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.
BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.
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Animal Model:
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Rats induced by ligation of left L5 and L6 spinal nerves.
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Dosage:
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5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.
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Administration:
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Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.
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Result:
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20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.
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BT-13
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-124401 | BT-13 | | 1 mg | 650元 |
| 2024/11/08 | HY-124401 | BT-13 | | 5 mg | 1700元 |
924537-98-4, BT-13 相关搜索:
- 抑制剂
- C23H27F4N3O4S
- N,N-二乙基-3-(4-(4-氟-2-(三氟甲基)苯甲酰基)哌嗪-1-基)-4-甲氧基苯磺酰胺
- 化合物BT-13
- 924537-98-4
- N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide
- RET,Inhibitor,BT-13,inhibit,BT13,BT 13
- BT-13
- Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-
- BT 13 NEW
- BT-13
(RET agonist BT13)
- 319H6