ChemicalBook >> CAS DataBase List >>BT-13
BT-13
- CAS No.
- 924537-98-4
- Chemical Name:
- BT-13
- Synonyms
- 319H6;BT-13;BT 13 NEW;BT-13 (RET agonist BT13);RET,Inhibitor,BT-13,inhibit,BT13,BT 13;N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide;Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-
- CBNumber:
- CB44840103
- Molecular Formula:
- C23H27F4N3O4S
- Molecular Weight:
- 517.54
- MDL Number:
- MOL File:
- 924537-98-4.mol
Last updated:2024-07-02 08:55:09
BT-13 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0086405 | BT-13 >99.0% | 924537-98-4 | 5mg | $180 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BB168381 | BT 13 NEW | 924537-98-4 | 10mg | $185 | 2021-12-16 | Buy |
| ChemScene | CS-0086405 | BT-13 >99.0% | 924537-98-4 | 10mg | $280 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BB168381 | BT 13 NEW | 924537-98-4 | 50mg | $647.5 | 2021-12-16 | Buy |
| ChemScene | CS-0086405 | BT-13 >99.0% | 924537-98-4 | 50mg | $850 | 2021-12-16 | Buy |
BT-13 Chemical Properties,Uses,Production
Biological Activity
BT-13 is a potent, selective agonist of the glial cell-derived neurotrophic factor (GDNF) receptor RET (acts independently of GDNF ligands), promotes sensory neuron neurite outgrowth in vitro, and alleviates neuropathy in rats happened.
in vitro
BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.
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in vivo
BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.
| Animal Model: | Rats induced by ligation of left L5 and L6 spinal nerves. |
| Dosage: | 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. |
| Administration: | Subcutaneous injections on post-surgical days 1, 3, 5, 8, 10, and 12. |
| Result: | 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia. |
target
GDNF receptor RET.
BT-13 Preparation Products And Raw materials
Raw materials
Preparation Products
BT-13 Suppliers
Global( 16)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 995 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3715 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62163 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23960 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 10010 | 58 |
319H6
BT-13
(RET agonist BT13)
BT 13 NEW
Benzenesulfonamide, N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]-1-piperazinyl]-4-methoxy-
BT-13
RET,Inhibitor,BT-13,inhibit,BT13,BT 13
N,N-diethyl-3-[4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl]-4-methoxybenzenesulfonamide
924537-98-4
C23H27F4N3O4S