化合物 T28017
中文名称 | 化合物 T28017 |
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中文同义词 | 化合物 T28017;MERBARONE CALBIOCHEM;4,6-二氧代-N-苯基-2-硫代六氢嘧啶-5-甲酰胺 |
英文名称 | MERBARONE |
英文同义词 | 5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;MERBARONE;4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide;Merbarone - CAS 97534-21-9 - Calbiochem |
CAS号 | 97534-21-9 |
分子式 | C11H9N3O3S |
分子量 | 263.27 |
EINECS号 | |
相关类别 | |
Mol文件 | 97534-21-9.mol |
结构式 |
化合物 T28017 性质
密度 | 1.51±0.1 g/cm3(Predicted) |
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储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:>5mg/mL |
形态 | 固体 |
酸度系数(pKa) | -2.16±0.20(Predicted) |
颜色 | 粉红至紫色 |
topoisomerase II
Merbarone (1-100 μM) inhibits L1210 cells proliferation in a concentration-dependent manner, with an IC
50
of 10 μM.
Merbarone (10-200 μM; 10 min) inhibits DNA relaxation catalyzed by human topoisomerase IIα, with an IC
50
of ∼40 μM.
Merbarone (25-200 μM; 6 min) blocks tyopoisomerase II-mediated DNA cleavage, with an IC
50
of ∼50 μM.
Merbarone (100 μM; 6 min) inhibits topoisomerase II-mediated DNA cleavage in a global manner.
Merbarone (100 μM; 6 min) does not impair topoisomerase II•DNA binding.
Merbarone (200 μM; 4-16 min) does not inhibit topoisomerase II-catalyzed ATP hydrolysis.
Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia.
Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice.
安全信息
WGK Germany | 3 |
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RTECS号 | UV7714625 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-19024 | 化合物 T28017 Merbarone | 97534-21-9 | 5mg | 550元 |
2024/08/19 | HY-19024 | Merbarone | 10 mg | 850元 |