化合物 T28017
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- CAS号:
- 97534-21-9
- 英文名:
- MERBARONE
- 英文别名:
- RLBN1001;RLBN-1001;MERBARONE;NSC-336628;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
- 中文名:
- 化合物 T28017
- 中文别名:
- 化合物 T28017;化合物 MERBARONE;MERBARONE CALBIOCHEM;4,6-二氧代-N-苯基-2-硫代六氢嘧啶-5-甲酰胺
- CBNumber:
- CB4494665
- 分子式:
- C11H9N3O3S
- 分子量:
- 263.27
- MOL File:
- 97534-21-9.mol
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化合物 T28017化学性质
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密度:
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1.51±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >5mg/mL
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形态:
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solid
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酸度系数(pKa):
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-2.16±0.20(Predicted)
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颜色:
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Pink to purple
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化合物 T28017性质、用途与生产工艺
Merbarone (NSC 336628) 是一种具有口服活性的拓扑异构酶 II (topoisomerase II) 抑制剂。Merbarone 的主要作用是阻断拓扑异构酶 II 介导的 DNA 切割,而不会稳定拓扑 II-DNA 共价复合物。Merbarone 具有抗肿瘤功效。
Merbarone (1-100 μM) inhibits L1210 cells proliferation in a concentration-dependent manner, with an IC
50
of 10 μM.
Merbarone (10-200 μM; 10 min) inhibits DNA relaxation catalyzed by human topoisomerase IIα, with an IC
50
of ∼40 μM.
Merbarone (25-200 μM; 6 min) blocks tyopoisomerase II-mediated DNA cleavage, with an IC
50
of ∼50 μM.
Merbarone (100 μM; 6 min) inhibits topoisomerase II-mediated DNA cleavage in a global manner.
Merbarone (100 μM; 6 min) does not impair topoisomerase II•DNA binding.
Merbarone (200 μM; 4-16 min) does not inhibit topoisomerase II-catalyzed ATP hydrolysis.
Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia.
Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice.
化合物 T28017
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-19024 | 化合物 T28017 Merbarone | 97534-21-9 | 5mg | 550元 |
2024/08/19 | HY-19024 | Merbarone | | 10 mg | 850元 |
97534-21-9, 化合物 T28017 相关搜索:
- 抑制剂
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Gene Regulation and Expression
- Tools for Gene Regulation Research
- Reagents
- 化合物 MERBARONE
- 4,6-二氧代-N-苯基-2-硫代六氢嘧啶-5-甲酰胺
- MERBARONE CALBIOCHEM
- 化合物 T28017
- 97534-21-9
- 4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
- 4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide , Merbarone
- RLBN-1001
- RLBN1001
- 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-
- Merbarone - CAS 97534-21-9 - Calbiochem
- 4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
- MERBARONE
- 5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
- hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid
- NSC-336628
- 5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID
- 5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID