머바론

머바론
머바론 구조식 이미지
카스 번호:
97534-21-9
한글명:
머바론
동의어(한글):
머바론
상품명:
MERBARONE
동의어(영문):
RLBN1001;RLBN-1001;MERBARONE;NSC-336628;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
CBNumber:
CB4494665
분자식:
C11H9N3O3S
포뮬러 무게:
263.27
MOL 파일:
97534-21-9.mol
MSDS 파일:
SDS

머바론 속성

밀도
1.51±0.1 g/cm3(Predicted)
저장 조건
2-8°C
용해도
에 용해됨 DMSO: >5mg/mL
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
-2.16±0.20(Predicted)
색상
Pink to purple

안전

WGK 독일 3
RTECS 번호 UV7714625

머바론 C화학적 특성, 용도, 생산

용도

Merbarone has been used to study its effect on the occurrence of DNA lesions.

일반 설명

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 μM for purified mammalian topo II versus IC50 = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

Biochem/physiol Actions

Cell permeable: yes

머바론 준비 용품 및 원자재

원자재

준비 용품


머바론 공급 업체

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