CL 316243
中文名称 | CL 316243 |
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中文同义词 | 化合物 T10830;CL 316243二钠盐;化合物CL 316243;5-[(2R)-2-[[(2R)-2-(3-氯苯基)-2-羟乙基]氨基]丙基]- 1,3-苯并二氧杂茂-2,2-二羧酸二钠水合物 |
英文名称 | CL 316243 |
英文同义词 | Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate hydrate;CL-316243 sodium;CL 316243;COLLAGEN FROM HUMAN LUNG;Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate;CL 316,243 hydrate;CL 316243 disodium (CL316243 disodium);inhibit,Adrenergic Receptor,CL 316243,Inhibitor,Beta Receptor,CL-316243,CL316243 |
CAS号 | 138908-40-4 |
分子式 | C20H18ClNO7.2Na |
分子量 | 465.795 |
EINECS号 | |
相关类别 | |
Mol文件 | 138908-40-4.mol |
结构式 | ![]() |
CL 316243 性质
储存条件 | room temp |
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溶解度 | H2O: >10 mg/mL |
形态 | 固体 |
颜色 | 白色 |
水溶解性 | Soluble to 100 mM in water |
EC50: 3 nM (β3-adrenoceptor)
CL 316243 displays binding affinities with IC 50 values of 0.6 μM and 1 μM for rat heart and rat soleus muscle respectively. CL 316243 inhibits spontaneously contracting, isolated rat detrusor strips in a concentration dependent manner with a mean concentration inhibiting 50% of maximal response of 2.65 nM.
CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 weeks) elevates the mRNA and protein expression levels of UCP1 in BAT, irrespective of diet.
Animal Model: | Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks |
Dosage: | 0.1 mg/kg/day |
Administration: | once a day; 1 weeks |
Result: | Exhibited a premium effect of obesity in mice. |
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-116771A | CL 316243 CL 316243 | 138908-40-4 | 5mg | 2500元 |
2024/04/30 | HY-116771A | CL 316243 CL 316243 | 138908-40-4 | 10 mM * 1 mLin Water | 2560元 |