磷苯妥英钠
中文名称 | 磷苯妥英钠 |
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中文同义词 | 2,4-咪唑啉二酮-5,5-二苯基-3-[(膦酰氧基)甲基]二钠盐;磷苯妥英钠;(2,5-二氧代-4,4-二苯基咪唑啉-1-基)甲基磷酸二钠盐;磷烯菌素二钠盐;苯妥英杂质11(磷苯妥英双钠盐) |
英文名称 | Fosphenytoin sodium |
英文同义词 | 5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt;Fosphenytoin Sodium (350 mg);FOSPHENYTOIN SODIUM;(sp-4-2)-5,5-diphenyl-3-((phosphonooxy)methyl)-2,4-imidazolidinedione disodium salt;FOSPENYTOIN;FOSPHENYTOIN DISODIUM SALT;5,5-Diphenyl-3-[[[di(sodiooxy)phosphinyl]oxy]methyl]-1H-imidazole-2,4(3H,5H)-dione;ACC-9653 |
CAS号 | 92134-98-0 |
分子式 | C16H16N2NaO6P |
分子量 | 386.28 |
EINECS号 | |
相关类别 | 神经系统用药;医药原料;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API |
Mol文件 | 92134-98-0.mol |
结构式 |
磷苯妥英钠 性质
熔点 | 220° (softens) |
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储存条件 | Inert atmosphere,2-8°C |
溶解度 | H2O:≥15mg/mL |
形态 | 粉末 |
颜色 | 白色至棕褐色 |
Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).
安全信息
危险品标志 | T |
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危险类别码 | 45-61-22 |
安全说明 | 53-36/37-45 |
危险品运输编号 | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
海关编码 | 2933290000 |
毒性 | LD50 in mice, rats (mg/kg): 234, 363 i.v. (Smith) |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S6482 | 磷苯妥英钠 Fosphenytoin (disodium) | 92134-98-0 | 5mg | 794.54元 |
2022/04/29 | S6482 | 磷苯妥英钠 Fosphenytoin (disodium) | 92134-98-0 | 100mg | 2842.84元 |