Company Name: |
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652 |
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sales@meilune.com |
Products Intro: |
Product Name:PDM2 CAS:688348-25-6 Purity:>98%,BR Package:10MG Remarks:MB0363
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| 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Basic information |
Product Name: | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE | Synonyms: | 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE;PDM 2;1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene;PDM-2;PDM2;PDM 2;688348-25-6;Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-;inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR;(E)-1,3-Dichloro-5-(4-chlorostyryl)benzene | CAS: | 688348-25-6 | MF: | C14H9Cl3 | MW: | 283.58 | EINECS: | | Product Categories: | | Mol File: | 688348-25-6.mol | ![1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Structure](CAS/GIF/688348-25-6.gif) |
| 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Chemical Properties |
Boiling point | 394.2±42.0 °C(Predicted) | density | 1.360±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml | form | A crystalline solid | color | White to off-white |
| 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Usage And Synthesis |
Description | The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 μM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings. |
| 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Preparation Products And Raw materials |
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