- Althiazide
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- $0.00 / 1KG
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2024-08-02
- CAS:5588-16-9
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000kg
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| Althiazide Basic information |
Product Name: | Althiazide | Synonyms: | ALTHIAZIDE;6-CHLORO-3,4-DIHYDRO-3-[(2-PROPENYLTHIO)METHYL]-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE;3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;P-1779;3-[(allylthio)methyl]-6-chloro-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;6-chloro-1,1-dioxo-3-(prop-2-enylsulfanylmethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;6-Chloro-3,4-dihydro-3-[(2-propen-1-ylthio)Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide;Althizide | CAS: | 5588-16-9 | MF: | C11H14ClN3O4S3 | MW: | 383.89 | EINECS: | 226-994-8 | Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium | Mol File: | 5588-16-9.mol | ![Althiazide Structure](CAS/GIF/5588-16-9.gif) |
| Althiazide Chemical Properties |
| Althiazide Usage And Synthesis |
Description | Althiazide, also known as altizide, is an agent belonging to the class of thiazide diuretics with antihypertensive activity. This aldosterone antagonist is often combined with spironolactone. | Chemical Properties | White Solid | Originator | Althiazide,Solchem | Uses | Diuretic and antihypertensive. | Definition | ChEBI: Althiazide is a benzothiadiazine. It is the thiazide and sulfonamide derivative. | Manufacturing Process | To 6.75 g (0.0225 mole) of 4-amino-2-chloro-5-(methylsulfamyl)
benzenesulfonamide in 45 ml of dimethylformamide is added 4.86 g (0.03
mole) of dimethyl allylmercaptoacetal followed by 1.5 ml ethyl acetate
saturated with hydrogen chloride gas. The solution is refluxed for 1.5 hours,
cooled and added dropwise with stirring to ice/water. The resulting precipitate
is filtered, dried and recrystallized from isopropanol. The recrystallization gave
4.0 g of 2-methyl-3-allylthiomethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide; M.P. 168.5-170°C. | Therapeutic Function | Diuretic, Antihypertensive |
| Althiazide Preparation Products And Raw materials |
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