促进成骨肽
| 中文名称 | 促进成骨肽 |
|---|---|
| 中文同义词 | 促进成骨肽 |
| 英文名称 | Dentonin |
| 英文同义词 | Dentonin;Dentonin (AC-100);AC-100;L-Aspartic acid, L-threonyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-α-glutamyl-L-arginylglycyl-L-α-aspartyl-L-asparaginyl-L-α-aspartyl-L-isoleucyl-L-seryl-L-prolyl-L-phenylalanyl-L-serylglycyl-L-α-aspartylglycyl-L-glutaminyl-L-prolyl-L-phenylalanyl-L-lysyl- |
| CAS号 | 400090-20-2 |
| 分子式 | C107H160N30O42 |
| 分子量 | 2538.63 |
| EINECS号 | |
| 相关类别 | 目录肽 |
| Mol文件 | 400090-20-2.mol |
| 结构式 |  |
促进成骨肽 性质
| 密度 | 1.58±0.1 g/cm3(Predicted) |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Dentonin (AC-100) 是 MEPE 来源的短肽片段。Dentonin 通过促进骨祖细胞粘附而促进成骨作用，并且可以促进未成熟的贴壁细胞存活。Dentonin 对成熟成骨细胞无显著影响。Dentonin 可用于磷酸盐稳态和骨代谢的研究。
MEPE is a a member of the SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) family of secreted glycophosphoproteins. MEPE regulates bone mass and influence osteoblast activity..Dentonin (3-30 μg/ml; 2-24 hours) significantly increases the numbers of cell and shows enhanced promotion of cell adhesion. However, it has no significant differences in terms of numbers of cells adhered.Dentonin (3-30 μg/ml; 2-24 hours) enhances osteoblast spreading, it exhibits significantly increased cell areas compared to all other treatment.