倍氯米松
| 中文名称 | 倍氯米松 |
|---|---|
| 中文同义词 | |
| 英文名称 | NEP |
| 英文同义词 | NEP |
| CAS号 | 2414276-32-5 |
| 分子式 | C29H31AsN4O5S2 |
| 分子量 | 654.63 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2414276-32-5.mol |
| 结构式 |  |
倍氯米松 性质
| 酸度系数(pKa) | 11.42±0.20(Predicted) |
|---|
NEP (VDP-green (NEP)) 是一种基于分子内电荷转移 (ICT) 机制的感应荧光探针，用于感应含邻二硫醇的蛋白质 (VDPs)。NEP 在活细胞和动物体内对 VDPs 表现出高选择性，并显示强绿色荧光信号 (λex/λem=430/535 nm)。NEP 具有用于帕金森氏症研究的潜力。
NEP (1-30 μM; 6 hours) has no or little cytotoxicity in HepG2 and PC12 cells.
NEP (10 μM; 4 hours) causes the fluorescence intensity to decrease gradually in PC12 cells pretreated with 6-OHDA (0, 50, 100, and 200 μM; for 30 min).
NEP contains a dithiarsolane moiety (five-membered As-S ring) as the receptor of VDPs. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. NEP maintains a reliable fluorescence response within the range of pH 7-10.
NEP (10 μM; for 4 h) causes the obvious green signal in zebrafishes (4 day old).